Gaayeb L., Sarr J. B., Cames Cécile, Pincon C., Hanon J. B., Ndiath M. O., Seck M., Herbert F., Sagna A. B., Schacht A. M., Remoué Franck, Riveau G., Hermann E. (2014). Effects of malnutrition on children's immunity to bacterial antigens in Northern Senegal. American Journal of Tropical Medicine and Hygiene, 90 (3), p. 566-573. ISSN 0002-9637.
Titre du document
Effects of malnutrition on children's immunity to bacterial antigens in Northern Senegal
Année de publication
2014
Auteurs
Gaayeb L., Sarr J. B., Cames Cécile, Pincon C., Hanon J. B., Ndiath M. O., Seck M., Herbert F., Sagna A. B., Schacht A. M., Remoué Franck, Riveau G., Hermann E.
Source
American Journal of Tropical Medicine and Hygiene, 2014,
90 (3), p. 566-573 ISSN 0002-9637
To evaluate immunity to vaccine-preventable diseases according to nutritional status, a longitudinal study was conducted in Senegalese children ages 1-9 years old. A linear regression analysis predicted that weight for age was positively associated with immunoglobulin G (IgG) response to tetanus toxoid in children born during the rainy season or at the beginning of the dry season. A relationship between village, time of visits, and levels of antibodies to tetanus showed that environmental factors played a role in modulating humoral immunity to tetanus vaccine over time. Moreover, a whole-blood stimulation assay highlighted that the production of interferon-gamma (IFN-gamma) in response to tetanus toxoid was compromised in stunted children. However, the absence of cytokine modulation in response to Mycobacterium tuberculosis-purified protein derivatives and phytohemagglutinin suggests that the overall ability to produce IFN-gamma was preserved in stunted children. Therefore, these results show that nutritional status can specifically alter the efficacy of long-lasting immunity to tetanus.
Plan de classement
Santé : généralités [050]
;
Nutrition, alimentation [054]
Description Géographique
SENEGAL
Localisation
Fonds IRD [F B010061845]
Identifiant IRD
fdi:010061845
