@article{fdi:010061814,
  title = {{P}attern of antibodies to the {D}uffy binding like domain of {P}lasmodium falciparum antigen {P}f332 in {S}enegalese individuals},
  author = {{B}alogun, {H}. {A}. and {A}wah, {N}. and {N}ilsson, {S}. and {R}ogier, {C}. and {T}rape, {J}ean-{F}ran{\c{c}}ois and {C}hen, {Q}. {J}. and {R}oussilhon, {C}. and {B}erzins, {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}cquisition of antibodies against blood stage antigens is crucial in malaria immunity and the {P}lasmodium falciparum antigen {P}f332, which is present in close association with the infected red blood cell membrane, is one such antigen. {I}n this study, the antibody response to a {D}uffy binding like fragment of {P}f332, termed {P}f332-{DBL} was investigated in sera from naturally exposed individuals living in {D}ielmo village, {S}enegal, with regard to immunoglobulin classes ({I}g{G}, {I}g{M}, {I}g{E}) and {I}g{G} subclasses ({I}g{G}1-4). {W}hile the levels of {I}g{M}, {I}g{G}, {I}g{G}1 and {I}g{G}2 only displayed a moderate trend to increase with age, {P}f332-{DBL} specific {I}g{G}3 levels increased significantly in the older villagers. {I}n multivariate analysis, when controlling for confounding factors, and in a linear model with a {P}oisson distribution, anti-{P}f332-{DBL} {I}g{G}3 as well as the ratio of cytophilic to non cytophilic anti-{P}f332-{DBL} antibodies were found significantly associated with a reduced risk of malaria attack. {T}his association was also present when the {I}g{G}3:{I}g{G}1 ratio was tested. {F}inally, two subgroups of villagers with the same mean age, were delineated by {I}g{G}3 concentrations either lower or higher than the median value. {A} total of 45.2% of the individuals with low anti-{P}f332-{DBL}-{I}g{G}3 levels but only 21.4% of the villagers in the group with high levels of such antibodies had a clinical malaria attack during a period of 3 years of continuous follow-up after the blood sampling. {I}n conclusion, {P}f332-{DBL} induces naturally the acquisition of antibodies, and {P}f332-{DBL}-specific {I}g{G}3 appears to be associated with protection against malaria in this endemic setting.},
  keywords = {{P}f332-{DBL} ; {A}ntibody response ; {I}g{G}3 subclass ; {I}mmunity ; {M}alaria attack ; {SENEGAL}},
  booktitle = {},
  journal = {{A}cta {T}ropica},
  volume = {130},
  numero = {},
  pages = {80--87},
  ISSN = {0001-706{X}},
  year = {2014},
  DOI = {10.1016/j.actatropica.2013.10.018},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061814},
}