@article{fdi:010061788,
  title = {{T}ime patterns of adherence and long-term virological response to non-nucleoside reverse transcriptase inhibitor regimens in the {S}tratall {ANRS} 12110/{ESTHER} trial in {C}ameroon},
  author = {{M}eresse, {M}. and {C}arrieri, {M}. {P}. and {L}aurent, {C}hristian and {K}ouanfack, {C}. and {P}rotopopescu, {C}. and {B}lanche, {J}. and {C}ohen, {J}. and {L}aborde-{B}alen, {G}. and {A}ghokeng {F}obang, {A}velin and {S}pire, {B}. and {M}oatti, {J}ean-{P}aul and {D}elaporte, {E}ric and {B}oyer, {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {A}lthough treatment adherence is a major challenge in sub-{S}aharan {A}frica, it is still unknown which longitudinal patterns of adherence are the most detrimental to long-term virological response to non-nucleoside reverse transcriptase inhibitor ({NNRTI}) regimens. {T}his analysis aimed to study the influence of different time patterns of adherence on virological failure after 24 months of treatment in {C}ameroon. {M}ethods: {A}ntiretroviral therapy ({ART}) adherence data were collected using face-to-face questionnaires administered at months 1, 3, 6, 12, 18 and 24. {V}irological failure was defined as viral load > 40 copies/ml at month 18 and/or 24. {T}wo combined indicators of early adherence (months 1, 3 and 6) and adherence during the maintenance phase (months 12, 18 and 24) were designed to classify patients as always adherent during the early or maintenance phase, non-adherent at least once and having interrupted {ART} for > 2 days at least once at any visit during either of these two phases. {R}esults: {V}irological failure occurred in 107 (42%) of the 254 patients included in the analysis. {I}n the early and maintenance phases, 84% and 76%, respectively, were always adherent, 5% and 5% were non-adherent and 11% and 20% experienced >= 1 treatment interruption. {E}arly non-adherence was independently associated with virological failure (adjusted {OR} 7.2 [95% {CI} 1.5, 34.6]), while only treatment interruptions had a significant impact on virological failure during the maintenance phase (adjusted {OR} 2.1 [95% {CI} 1.1, 4.4]). {C}onclusions: {ART} {NNRTI}-regimens used in sub-{S}aharan {A}frica seem to 'forgive' deviations from good adherence during the maintenance phase. {O}ptimizing adherence in the early months of treatment remains crucial, especially in a setting of poor health care infrastructure and resources.},
  keywords = {{CAMEROUN}},
  booktitle = {},
  journal = {{A}ntiviral {T}herapy},
  volume = {18},
  numero = {1},
  pages = {29--37},
  ISSN = {1359-6535},
  year = {2013},
  DOI = {10.3851/imp2535},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061788},
}