@article{fdi:010061636,
  title = {{T}esting for post-copulatory selection for major histocompatibility complex genotype in a semi-free-ranging primate population},
  author = {{S}etchell, {J}.{M}. and {A}bbott, {K}.{M}. and {G}onzalez, {J}ean-{P}aul and {K}napp, {L}.{A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A} large body of evidence suggests that major histocompatibility complex ({MHC}) genotype influences mate choice. {H}owever, few studies have investigated {MHC}-mediated post-copulatory mate choice under natural, or even semi-natural, conditions. {W}e set out to explore this question in a large semi-free-ranging population of mandrills ({M}andrillus sphinx) using {MHC}-{DRB} genotypes for 127 parent-offspring triads. {F}irst, we showed that offspring {MHC} heterozygosity correlates positively with parental {MHC} dissimilarity suggesting that mating among {MHC} dissimilar mates is efficient in increasing offspring {MHC} diversity. {S}econd, we compared the haplotypes of the parental dyad with those of the offspring to test whether post-copulatory sexual selection favored offspring with two different {MHC} haplotypes, more diverse gamete combinations, or greater within-haplotype diversity. {L}imited statistical power meant that we could only detect medium or large effect sizes. {N}evertheless, we found no evidence for selection for heterozygous offspring when parents share a haplotype (large effect size), genetic dissimilarity between parental haplotypes (we could detect an odds ratio of 1.86), or within-haplotype diversity (medium-large effect). {T}hese findings suggest that comparing parental and offspring haplotypes may be a useful approach to test for post-copulatory selection when matings cannot be observed, as is the case in many study systems. {H}owever, it will be extremely difficult to determine conclusively whether post-copulatory selection mechanisms for {MHC} genotype exist, particularly if the effect sizes are small, due to the difficulty in obtaining a sufficiently large sample.},
  keywords = {{PRIMATE} ; {GENOTYPE} ; {REPRODUCTION} {SEXUEE} ; {HETEROZYGOTE} ; {GAMETE} ; {SELECTION} ; {HAPLOTYPE} ; {DIVERSITE} {GENETIQUE} ; {ELECTROPHORESE} ; {TECHNIQUE} {PCR} ; {GABON}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {P}rimatology},
  volume = {75},
  numero = {10},
  pages = {1021--1031},
  ISSN = {0275-2565},
  year = {2013},
  DOI = {10.1002/ajp.22166},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061636},
}