@article{fdi:010061618, title = {{T}he evolution of resistance to {S}imian {I}mmunodeficiency {V}irus ({SIV})}, author = {{L}ocatelli, {S}abrina and {M}c{K}ean, {K}.{A}. and {S}esink {C}lee, {P}.{R}. and {G}onder, {M}.{K}.}, editor = {}, language = {{ENG}}, abstract = {{E}xamining how pathogens cross species boundaries, spread within species, and persist within their hosts is an essential part of understanding the factors that underpin the evolution of virulence and host resistance. {H}ere, we review current knowledge about the genetic diversity, molecular epidemiology, prevalence, and pathogenicity of simian immunodeficiency viruses ({SIV}s). {SIV}s have crossed species boundaries from simian hosts to humans on at least 12 separate occasions, one of which led to the global {HIV}–{AIDS} crisis. {T}hough {SIV}s infect a wide range of primates, scientists have only recently begun to describe the natural history of {SIV} infection in their natural hosts. {S}everal new studies reveal how both viral and host factors are responsible for the transmission to, and adaptation in, new hosts. {T}hese studies also suggest that the spread of the virus may be affected by host-specific traits, including social structure, mating system and demographic history. {T}hese studies challenge the traditional view that {SIV} is relatively benign in its natural host, and instead suggest that a highly dynamic relationship exists between {SIV} and its simian hosts.}, keywords = {{SIDA} ; {VIRUS} ; {INFECTION} ; {PRIMATE} ; {HOMME} ; {AGENT} {PATHOGENE} ; {PREVALENCE} ; {VIRULENCE} ; {RESISTANCE} {DE} {L}'{HOTE} ; {BIOLOGIE} {MOLECULAIRE} ; {EPIDEMIOLOGIE} ; {REPARTITION} {GEOGRAPHIQUE} ; {TRANSMISSION} ; {COMPORTEMENT} ; {FACTEUR} {ECOLOGIQUE} ; {DIVERSITE} {GENETIQUE} ; {ORIGINE} {GEOGRAPHIQUE} ; {ZONE} {TROPICALE}}, booktitle = {}, journal = {{I}nternational {J}ournal of {P}rimatology}, volume = {35}, numero = {2}, pages = {349--375}, ISSN = {0164-0291}, year = {2014}, DOI = {10.1007/s10764-014-9763-7}, URL = {https://www.documentation.ird.fr/hor/fdi:010061618}, }