Locatelli Sabrina, McKean K.A., Sesink Clee P.R., Gonder M.K. (2014). The evolution of resistance to Simian Immunodeficiency Virus (SIV). International Journal of Primatology, 35 (2), p. 349-375. ISSN 0164-0291.
Titre du document
The evolution of resistance to Simian Immunodeficiency Virus (SIV)
International Journal of Primatology, 2014,
35 (2), p. 349-375 ISSN 0164-0291
Examining how pathogens cross species boundaries, spread within species, and persist within their hosts is an essential part of understanding the factors that underpin the evolution of virulence and host resistance. Here, we review current knowledge about the genetic diversity, molecular epidemiology, prevalence, and pathogenicity of simian immunodeficiency viruses (SIVs). SIVs have crossed species boundaries from simian hosts to humans on at least 12 separate occasions, one of which led to the global HIV–AIDS crisis. Though SIVs infect a wide range of primates, scientists have only recently begun to describe the natural history of SIV infection in their natural hosts. Several new studies reveal how both viral and host factors are responsible for the transmission to, and adaptation in, new hosts. These studies also suggest that the spread of the virus may be affected by host-specific traits, including social structure, mating system and demographic history. These studies challenge the traditional view that SIV is relatively benign in its natural host, and instead suggest that a highly dynamic relationship exists between SIV and its simian hosts.
