@article{fdi:010061576,
  title = {{R}apid diagnostic tests for neurological infections in central {A}frica},
  author = {{Y}ansouni, {C}.{P}. and {B}ottieau, {E}. and {L}utumba, {P}. and {W}inkler, {A}.{S}. and {L}ynen, {L}. and {B}uscher, {P}. and {J}acobs, {J}. and {G}illet, {P}. and {L}ejon, {V}eerle and {A}lirol, {E}. and {P}olman, {K}. and {U}tzinger, {J}. and {M}iles, {M}.{M}. and {P}eeling, {R}.{W}. and {M}uyembe, {J}.{J}. and {C}happuis, {F}. and {B}oelaert, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}nfections are a leading cause of life-threatening neuropathology worldwide. {I}n central {A}frican countries affected by endemic diseases such as human {A}frican trypanosomiasis, tuberculosis, {HIV}/{AIDS}, and schistosomiasis, delayed diagnosis and treatment often lead to avoidable death or severe sequelae. {C}onfirmatory microbiological and parasitological tests are essential because clinical features of most neurological infections are not specific, brain imaging is seldom feasible, and treatment regimens are often prolonged or toxic. {R}ecognition of this diagnostic bottleneck has yielded major investment in application of advances in biotechnology to clinical microbiology in the past decade. {W}e review the neurological pathogens for which rapid diagnostic tests are most urgently needed in central {A}frica, detail the state of development of putative rapid diagnostic tests for each, and describe key technical and operational challenges to their development and implementation. {P}romising field-suitable rapid diagnostic tests exist for the diagnosis of human {A}frican trypanosomiasis and cryptococcal meningoencephalifis. {F}or other infections-eg, syphilis and schistosomiasis highly accurate field-validated rapid diagnostic tests are available, but their role in diagnosis of disease with neurological involvement is still unclear. {F}or others-eg, tuberculosis-advances in research have not yet yielded validated tests for diagnosis of neurological disease.},
  keywords = {{TRYPANOSOMIASE} {HUMAINE} ; {SCHISTOSOMIASE} ; {DIAGNOSTIC} ; {METHODE} {BIOLOGIQUE} ; {AGENT} {PATHOGENE} ; {FLUIDE} {CEREBROSPINAL} ; {NEUROPATHIE} ; {AFRIQUE} {CENTRALE} ; {ANGOLA} ; {REPUBLIQUE} {DEMOCRATIQUE} {DU} {CONGO}},
  booktitle = {},
  journal = {{L}ancet {I}nfectious {D}iseases},
  volume = {13},
  numero = {6},
  pages = {546--558},
  ISSN = {1473-3099},
  year = {2013},
  DOI = {10.1016/{S}1473-3099(13)70004-5},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061576},
}