@article{fdi:010061569,
  title = {{N}ew biomarkers for stage determination in {T}rypanosoma brucei rhodesiense sleeping sickness patients},
  author = {{T}iberti, {N}. and {M}atovu, {E}. and {H}ainard, {A}. and {E}nyaru, {J}.{C}. and {L}ejon, {V}eerle and {R}obin, {X}. and {T}urck, {N}. and {M}umba {N}goyi, {D}. and {K}rishna, {S}. and {B}isser, {S}. and {C}ourtioux, {B}. and {B}üscher, {P}. and {K}ristensson, {K}. and {M}athu {N}dung'u, {J}. and {S}anchez, {J}.{C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}ccurate stage determination is crucial in the choice of treatment for patients suffering from sleeping sickness, also known as human {A}frican trypanosomiasis ({HAT}). {C}urrent staging methods, based on the counting of white blood cells ({WBC}) and the detection of parasites in the cerebrospinal fluid ({CSF}) have limited accuracy. {W}e hypothesized that immune mediators reliable for staging {T}. b. gambiense {HAT} could also be used to stratify {T}. b. rhodesiense patients, the less common form of {HAT}.{A} population comprising 85 {T}. b. rhodesiense patients, 14 stage 1 ({S}1) and 71 stage 2 ({S}2) enrolled in {M}alawi and {U}ganda, was investigated. {T}he {CSF} levels of {I}g{M}, {MMP}-9, {CXCL}13, {CXCL}10, {ICAM}-1, {VCAM}-1, neopterin and {B}2{MG} were measured and their staging performances evaluated using receiver operating characteristic ({ROC}) analyses.{I}g{M}, {MMP}-9 and {CXCL}13 were the most accurate markers for stage determination (partial {AUC} 88%, 86% and 85%, respectively). {T}he combination in panels of three molecules comprising {CXCL}13-{CXCL}10-{MMP}-9 or {CXCL}13-{CXCL}10-{I}g{M} significantly increased their staging ability to partial {AUC} 94% (p value < 0.01).{T}he present study highlighted new potential markers for stage determination of {T}. b. rhodesiense patients. {F}urther investigations are needed to better evaluate these molecules, alone or in panels, as alternatives to {WBC} to make reliable choice of treatment.},
  keywords = {{TRYPANOSOMIASE} {HUMAINE} ; {DIAGNOSTIC} ; {METHODE} {BIOLOGIQUE} ; {BIOMARQUEUR} ; {FLUIDE} {CEREBROSPINAL} ; {AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{C}linical and {T}ranslational {M}edicine},
  volume = {2},
  numero = {1},
  pages = {8  [en ligne]},
  ISSN = {2001-1326},
  year = {2013},
  DOI = {10.1186/2001-1326-2-1},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061569},
}