@article{fdi:010061491,
  title = {{I}ntegration of hormonal signaling networks and mobile micro{RNA}s is required for vascular patterning in {A}rabidopsis roots},
  author = {{M}uraro, {D}. and {M}ellor, {N}. and {P}ound, {M}. {P}. and {H}elp, {H}. and {L}ucas, {M}ika{\¨e}l and {C}hopard, {J}. and {B}yrne, {H}. {M}. and {G}odin, {C}. and {H}odgman, {T}. {C}. and {K}ing, {J}. {R}. and {P}ridmore, {T}. {P}. and {H}elariutta, {Y}. and {B}ennett, {M}. {J}. and {B}ishopp, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}s multicellular organisms grow, positional information is continually needed to regulate the pattern in which cells are arranged. {I}n the {A}rabidopsis root, most cell types are organized in a radially symmetric pattern; however, a symmetry-breaking event generates bisymmetric auxin and cytokinin signaling domains in the stele. {B}idirectional cross-talk between the stele and the surrounding tissues involving a mobile transcription factor, {SHORT} {ROOT} ({SHR}), and mobile micro{RNA} species also determines vascular pattern, but it is currently unclear how these signals integrate. {W}e use a multicellular model to determine a minimal set of components necessary for maintaining a stable vascular pattern. {S}imulations perturbing the signaling network show that, in addition to the mutually inhibitory interaction between auxin and cytokinin, signaling through {SHR}, micro{RNA}165/6, and {PHABULOSA} is required to maintain a stable bisymmetric pattern. {W}e have verified this prediction by observing loss of bisymmetry in shr mutants. {T}he model reveals the importance of several features of the network, namely the mutual degradation of micro{RNA}165/6 and {PHABULOSA} and the existence of an additional negative regulator of cytokinin signaling. {T}hese components form a plausible mechanism capable of patterning vascular tissues in the absence of positional inputs provided by the transport of hormones from the shoot.},
  keywords = {mathematical modeling ; plant development},
  booktitle = {},
  journal = {{P}roceedings of the {N}ational {A}cademy of {S}ciences of the {U}nited {S}tates of {A}merica},
  volume = {111},
  numero = {2},
  pages = {857--862},
  ISSN = {0027-8424},
  year = {2014},
  DOI = {10.1073/pnas.1221766111},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061491},
}