@article{fdi:010061484,
  title = {{I}n vitro antidermatophytic activity of {O}tacanthus azureus ({L}inden) {R}onse essential oil alone and in combination with azoles},
  author = {{H}ouel, {E}. and {R}odrigues, {A}. {M}. {S}. and {J}ahn-{O}yac, {A}. and {B}essi{\`e}re, {J}. {M}. and {E}parvier, {V}. and {D}eharo, {E}ric and {S}tien, {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}ims{W}e determined the chemical composition and investigated the antifungal activity of {O}tacanthus azureus ({L}inden) {R}onse essential oil ({EO}) against a range of dermatophytes alone or in combination with azole antifungals. {M}ethods and {R}esults{A}erial parts of the plant were steam-distilled and the obtained oil was analysed by gas chromatography/mass spectrometry and {H}-1-{NMR}. {I}t was shown to be largely composed of sesquiterpenes, with the main component being -copaen-4--ol. {U}sing broth microdilution techniques, this oil was found to have remarkable in vitro antifungal activities. {M}inimum inhibitory concentrations as low as 4g ml(-1) were recorded. {T}he analysis of the combined effect of the {O}. azureus {EO} with azoles using chequerboard assays revealed a synergism between the {EO} and ketoconazole, fluconazole or itraconazole against {T}richophyton mentagrophytes. {N}otably, the {O}. azureus essential oil showed low cytotoxicity to {VERO} cells. {C}onclusions{T}he {O}. azureus essential oil alone or in combination with azoles is a promising antifungal agent in the treatment for human dermatomycoses caused by filamentous fungi. {S}ignificance and {I}mpact of the {S}tudy{T}here is much interest in the study of essential oils for the discovery of new antimicrobial drugs. {T}his study has highlighted the antidermatophytic activity of the {O}. azureus {EO}.},
  keywords = {antifungal activity ; azoles ; dermatophytes ; essential oil ; {O}tacanthus azureus ; synergy},
  booktitle = {},
  journal = {{J}ournal of {A}pplied {M}icrobiology},
  volume = {116},
  numero = {2},
  pages = {288--294},
  ISSN = {1364-5072},
  year = {2014},
  DOI = {10.1111/jam.12377},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061484},
}