@article{fdi:010061478,
  title = {{N}europrotective effects of rosmarinic acid on ciguatoxin in primary human neurons},
  author = {{B}raidy, {N}. and {M}atin, {A}. and {R}ossi, {F}. and {C}hinain, {M}. and {L}aurent, {D}ominique and {G}uillemin, {G}. {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}iguatoxin ({CTX}), is a toxic compound produced by microalgae (dinoflagellate) {G}ambierdiscus spp., and is bio-accumulated and bio-transformed through the marine food chain causing neurological deficits. {T}o determine the mechanism of {CTX}-mediated cytotoxicity in human neurons, we measured extracellular lactate dehydrogenase ({LDH}) activity, intracellular levels of nicotinamide adenine dinucleotide ({NAD}(+)) and {H}2{AX} phosphorylation at serine 139 as a measure for {DNA} damage in primary cultures of human neurons treated with {P}acific ({P})-{CTX}-1{B} and {P}-{CTX}-3{C}. {W}e found these marine toxins can induce a time and dose-dependent increase in extracellular {LDH} activity, with a concomitant decline in intracellular {NAD}(+) levels and increased {DNA} damage at the concentration range of 5-200 n{M}. {W}e also showed that pre- and post-treatment with rosmarinic acid ({RA}), the active constituent of the {H}eliotropium foertherianum ({B}oraginaceae) can attenuate {CTX}-mediated neurotoxicity. {T}hese results further highlight the potential of {RA} in the treatment of {CTX}-induced neurological deficits.},
  keywords = {{C}iguatera ; {C}iguatoxin ; {DNA} damage ; {NAD}(+) ; {N}eurotoxicity ; {R}osmarinic acid},
  booktitle = {},
  journal = {{N}eurotoxicity {R}esearch},
  volume = {25},
  numero = {2},
  pages = {226--234},
  ISSN = {1029-8428},
  year = {2014},
  DOI = {10.1007/s12640-013-9429-9},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061478},
}