@article{fdi:010061398,
  title = {{P}ostpartum weight change among {HIV}-infected mothers by antiretroviral prophylaxis and infant feeding modality in a research setting},
  author = {{C}ames, {C}{\'e}cile and {C}ournil, {A}mandine and de {V}incenzi, {I}. and {G}aillard, {P}. and {M}eda, {N}. and {L}uchters, {S}. and {N}duati, {R}. and {N}aidu, {K}. and {N}ewell, {M}. {L}. and {R}ead, {J}. {S}. and {B}ork, {K}irsten},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjective:{T}o assess the relationship between infant feeding, triple-antiretroviral prophylaxis and weight from 2 weeks (baseline) to 6 months postpartum among {HIV}-infected mothers in a mother-to-child transmission ({MTCT}) of {HIV}-prevention trial in five sub-{S}aharan {A}frican sites.{M}ethods:{HIV}-infected pregnant women with {CD}4(+) cell counts of 200-500cells/l were counselled to choose breastfeeding to 6 months or replacement feeding from delivery. {T}hey were randomized to receive perinatal zidovudine and single-dose nevirapine or triple-antiretroviral {MTCT} prophylaxis until breastfeeding cessation. {M}ixed-effect linear models were used to compare maternal weight trajectories over time by infant feeding mode. {A}ntiretroviral prophylaxis and {BMI} at baseline were examined as potential effect modifiers.{R}esults:{A}mong 797 mothers, 620 (78%) initiated breastfeeding. {W}asting ({BMI} <18.5) was rare at baseline (2%), whereas overweight/obesity ({BMI}25) was common (40%). {I}n the model including all women, breastfeeding was not associated with weight loss up to 6 months, irrespective of baseline {BMI} and antiretroviral prophylaxis. {T}riple-antiretroviral prophylaxis was associated with weight gain among replacement-feeding mothers with baseline {BMI} at least 25 (+0.54kg/month; {P}<0.0001). {I}n the model including breastfeeding mothers only, triple-antiretroviral prophylaxis was associated with weight gain among mothers with baseline {BMI} at least 25 who ceased breastfeeding before 3 months postpartum (+0.33kg/month; {P}=0.03).{C}onclusion:{T}he results suggest that breastfeeding up to 6 months postpartum is not detrimental for postpartum weight among well nourished {HIV}-infected mothers at intermediate-disease stage. {I}n the absence of breastfeeding or after weaning, triple-antiretroviral prophylaxis is associated with weight gain among women with high {BMI}, even after cessation of prophylaxis.},
  keywords = {{A}frica ; antiretroviral prophylaxis ; body weight change ; breastfeeding ; {HIV} infection ; overweight ; {AFRIQUE} {SUBSAHARIENNE} ; {BURKINA} {FASO} ; {KENYA} ; {AFRIQUE} {DU} {SUD}},
  booktitle = {},
  journal = {{A}ids},
  volume = {28},
  numero = {1},
  pages = {85--94},
  ISSN = {0269-9370},
  year = {2014},
  DOI = {10.1097/01.aids.0000433243.24481.c3},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061398},
}