@article{fdi:010061375,
  title = {{I}mpact of pregnancy-associated malaria on infant malaria infection in {S}outhern {B}enin},
  author = {{B}orgella, {S}. and {F}ievet, {N}adine and {H}uynh, {B}. {T}. and {I}bitokou, {S}. and {H}ounguevou, {G}. and {A}ffedjou, {J}. and {S}agbo, {J}. {C}. and {H}oungbegnon, {P}. and {G}uezo-{M}evo, {B}. and {M}assougbodji, {A}. and {L}uty, {A}drian and {C}ot, {M}ichel and {D}eloron, {P}hilippe},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {I}nfants of mothers with placental {P}lasmodium falciparum infections at delivery are themselves more susceptible to malaria attacks or to infection in early life. {M}ethodology/{P}rincipal {F}indings: {T}o assess the impact of either the timing or the number of pregnancy-associated malaria ({PAM}) infections on the incidence of parasitemia or malaria attacks in infancy, we followed 218 mothers through pregnancy (monthly visits) up to delivery and their infants from birth to 12 months of age (fortnightly visits), collecting detailed clinical and parasitological data. {A}fter adjustment on location, mother's age, birth season, bed net use, and placental malaria, infants born to a mother with {PAM} during the third trimester of pregnancy had a significantly increased risk of infection ({OR} [95% {CI}]: 4.2 [1.6; 10.5], p = 0.003) or of malaria attack (4.6 [1.7; 12.5], p = 0.003). {PAM} during the first and second trimesters had no such impact. {S}imilarly significant results were found for the effect of the overall number of {PAM} episodes on the time to first parasitemia and first malaria attack ({HR} [95% {CI}]: 2.95 [1.58; 5.50], p = 0.001 and 3.19 [1.59; 6.38], p = 0.001) respectively. {C}onclusions/{S}ignificance: {T}his study highlights the importance of protecting newborns by preventing repeated episodes of {PAM} in their mothers.},
  keywords = {{BENIN}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {8},
  numero = {11},
  pages = {e80624},
  ISSN = {1932-6203},
  year = {2013},
  DOI = {10.1371/journal.pone.0080624},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061375},
}