@article{fdi:010061335,
  title = {{I}nsights on the {HLA}-{G} evolutionary history provided by a nearby {A}lu insertion},
  author = {{S}antos, {K}. {E}. and {L}ima, {T}. {H}. {A}. and {F}elicio, {L}. {P}. and {M}assaro, {J}. {D}. and {P}alomino, {G}. {M}. and {S}ilva, {A}. {C}. {A}. and {O}liveira, {S}. {F}. and {S}abbagh, {A}. and {G}arcia, {A}ndr{\'e} and {M}oreau, {P}. and {D}onadi, {E}. {A}. and {M}endes-{J}unior, {C}. {T}. and {C}astelli, {E}. {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he {A}luy{HG} element belongs to the {A}lu{Y}b8 subfamily. {I}t is a polymorphic insertion, located approximately 20 kb from the {HLA}-{G} 3'-untranslated region (3'-{UTR}), which has been used for evolution studies because it exhibits identity for descendants and it is still polymorphic in the human genome. {T}o understand the evolutionary mechanisms acting on {HLA}-{G}, we evaluated the presence or absence of the {A}luy{HG} element, associating this variable site with others observed at {HLA}-{G} coding, 3'-{UTR}, or both regions in four distinct populations ({B}razilian, {F}rench, {C}ongolese, and {S}enegalese). {T}he results were compared with the 1000{G}enomes {C}onsortium data. {T}he worldwide {A}luy{HG} frequencies showed an increment, starting lower in {A}frica and increasing following distance and time of human dispersion out of {A}frica. {T}he same haplotype pattern was observed in all populations, indicating that most of the {HLA}-{G} haplotypes already detected were originated earlier in {A}frica, before {H}omo sapiens dispersion. {T}he {A}luy{HG} insertion was associated with the {G}*01:01:01:01/{UTR}-1 haplotype, with rare recombinants. {D}espite its high frequency in worldwide populations, the {G}*01:01:01:01/{UTR}-1 haplotype should be very recent. {T}he low frequency of recombinants indicates that the rate of recombination at the {HLA}-{G} gene is very low.},
  keywords = {{A}luy{HG} ; {HLA}-{G} ; 3'-untranslated region ; haplotypes ; worldwide diversity ; human evolution ; {BRESIL} ; {CONGO} ; {FRANCE} ; {SENEGAL}},
  booktitle = {},
  journal = {{M}olecular {B}iology and {E}volution},
  volume = {30},
  numero = {11},
  pages = {2423--2434},
  ISSN = {0737-4038},
  year = {2013},
  DOI = {10.1093/molbev/mst142},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061335},
}