Publications des scientifiques de l'IRD

Santos K. E., Lima T. H. A., Felicio L. P., Massaro J. D., Palomino G. M., Silva A. C. A., Oliveira S. F., Sabbagh A., Garcia André, Moreau P., Donadi E. A., Mendes-Junior C. T., Castelli E. C. (2013). Insights on the HLA-G evolutionary history provided by a nearby Alu insertion. Molecular Biology and Evolution, 30 (11), p. 2423-2434. ISSN 0737-4038.

Titre du document
Insights on the HLA-G evolutionary history provided by a nearby Alu insertion
Année de publication
2013
Type de document
Article référencé dans le Web of Science WOS:000326745300004
Auteurs
Santos K. E., Lima T. H. A., Felicio L. P., Massaro J. D., Palomino G. M., Silva A. C. A., Oliveira S. F., Sabbagh A., Garcia André, Moreau P., Donadi E. A., Mendes-Junior C. T., Castelli E. C.
Source
Molecular Biology and Evolution, 2013, 30 (11), p. 2423-2434 ISSN 0737-4038
The AluyHG element belongs to the AluYb8 subfamily. It is a polymorphic insertion, located approximately 20 kb from the HLA-G 3'-untranslated region (3'-UTR), which has been used for evolution studies because it exhibits identity for descendants and it is still polymorphic in the human genome. To understand the evolutionary mechanisms acting on HLA-G, we evaluated the presence or absence of the AluyHG element, associating this variable site with others observed at HLA-G coding, 3'-UTR, or both regions in four distinct populations (Brazilian, French, Congolese, and Senegalese). The results were compared with the 1000Genomes Consortium data. The worldwide AluyHG frequencies showed an increment, starting lower in Africa and increasing following distance and time of human dispersion out of Africa. The same haplotype pattern was observed in all populations, indicating that most of the HLA-G haplotypes already detected were originated earlier in Africa, before Homo sapiens dispersion. The AluyHG insertion was associated with the G*01:01:01:01/UTR-1 haplotype, with rare recombinants. Despite its high frequency in worldwide populations, the G*01:01:01:01/UTR-1 haplotype should be very recent. The low frequency of recombinants indicates that the rate of recombination at the HLA-G gene is very low.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
Description Géographique
BRESIL ; CONGO ; FRANCE ; SENEGAL
Localisation
Fonds IRD [F B010061335]
Identifiant IRD
fdi:010061335
Contact