@article{fdi:010061291,
  title = {{R}elationship between mortality and feeding modality among children born to {HIV}-infected mothers in a research setting : the {K}esho {B}ora {S}tudy},
  author = {{C}ournil, {A}mandine and {D}e {V}incenzi, {I}. and {G}aillard, {P}. and {C}ames, {C}{\'e}cile and {F}ao, {P}. and {L}uchters, {S}. and {R}ollins, {N}. and {N}ewell, {M}. {L}. and {B}ork, {K}irsten and {R}ead, {J}. {S}. and {K}esho {B}ora {S}tudy {G}rp,},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjective:{T}o assess the relationship between infant feeding practices and mortality by 18 months of age among children born to {HIV}-infected mothers in the {K}esho {B}ora trial ({B}urkina-{F}aso, {K}enya and {S}outh {A}frica).{M}ethods:{E}nrolled {HIV}-infected women were counseled to choose between breastfeeding up to 6 months or replacement feeding from delivery. {M}ultivariable {C}ox models were used to compare the infant mortality risks according to feeding practices over time defined as never breastfed, weaned or still breastfed. {T}he category still breastfed' was disaggregated as exclusively, predominantly or partially breastfed to compare modes of breastfeeding. {T}he relationship between weaning and mortality was also assessed using marginal structural models to control for time-dependent confounders, such as maternal or infant morbidity (reverse causality).{R}esults:{A}mong 795 mothers, 618 (77.7%) initiated breastfeeding. {M}ortality rates by 18 months among uninfected and infected children were 6 and 38%, respectively. {N}ever breastfed and weaned children were at greater risk of death compared with those still breastfed. {A}djusted hazard ratios were 6.7 [95% confidence interval ({CI})=2.5-17.9; {P}<0.001] and 6.9 ({CI}=2.8-17.2; {P}<0.001) for never breastfed and weaned children, respectively. {E}stimation of the effect of weaning using marginal structural models led to similar results. {N}o statistically significant differences were observed according to mode of breastfeeding (exclusive, predominant or partial).{C}onclusion:{W}ithin 6 months after birth, weaned or never breastfed children were at about seven-fold higher risk of dying compared with children who were still breastfed despite a context in which interventions were provided to reduce risks associated with replacement feeding.},
  keywords = {{A}frica ; breastfeeding ; {HIV}-exposed children ; marginal structural models ; mortality ; replacement feeding ; {BURKINA} {FASO} ; {KENYA} ; {AFRIQUE} {DE} {L}'{OUEST}},
  booktitle = {},
  journal = {{A}ids},
  volume = {27},
  numero = {10},
  pages = {1621--1630},
  ISSN = {0269-9370},
  year = {2013},
  DOI = {10.1097/{QAD}.0b013e32835d5226},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061291},
}