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Pocquet Nicolas, Milesi P., Makoundou P., Unal S., Zumbo B., Atyame C., Darriet Frédéric, Dehecq J. S., Thiria J., Bheecarry A., Iyaloo D. P., Weill M., Chandre Fabrice, Labbé P. (2013). Multiple insecticide resistances in the disease vector Culex p. quinquefasciatus from Western Indian Ocean. Plos One, 8 (10), e77855. ISSN 1932-6203

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Lien direct chez l'éditeur doi:10.1371/journal.pone.0077855

Titre
Multiple insecticide resistances in the disease vector Culex p. quinquefasciatus from Western Indian Ocean
Année de publication2013
Type de documentArticle référencé dans le Web of Science WOS:000326032600051
AuteursPocquet Nicolas, Milesi P., Makoundou P., Unal S., Zumbo B., Atyame C., Darriet Frédéric, Dehecq J. S., Thiria J., Bheecarry A., Iyaloo D. P., Weill M., Chandre Fabrice, Labbé P.
SourcePlos One, 2013, 8 (10), p. e77855. p. e77855 ISSN 1932-6203
RésuméSeveral mosquito-borne diseases affect the Western Indian Ocean islands. Culex pipiens quinquefasciatus is one of these vectors and transmits filariasis, Rift Valley and West Nile viruses and the Japanese encephalitis. To limit the impact of these diseases on public health, considerable vector control efforts have been implemented since the 50s, mainly through the use of neurotoxic insecticides belonging to Organochlorines (OC), Organophosphates (OP) and pyrethroids (PYR) families. However, mosquito control failures have been reported on site, and they were probably due to the selection of resistant individuals in response to insecticide exposure. In this study, we used different approaches to establish a first regional assessment of the levels and mechanisms of resistance to various insecticides. Bioassays were used to evaluate resistance to various insecticides, enzyme activity was measured to assess the presence of metabolic resistances through elevated detoxification, and molecular identification of known resistance alleles was investigated to determine the frequency of target-site mutations. These complementary approaches showed that resistance to the most used insecticides families (OC, OP and PYR) is widespread at a regional scale. However, the distribution of the different resistance genes is quite heterogeneous among the islands, some being found at high frequencies everywhere, others being frequent in some islands and absent in others. Moreover, two resistance alleles displayed clinal distributions in Mayotte and La Reunion, probably as a result of a heterogeneous selection due to local treatment practices. These widespread and diverse resistance mechanisms reduce the capacity of resistance management through classical strategies (e. g. insecticide rotation). In case of a disease outbreak, it could undermine the efforts of the vector control services, as only few compounds could be used. It thus becomes urgent to find alternatives to control populations of Cx. p. quinquefasciatus in the Indian Ocean.
Plan de classementEntomologie médicale / Parasitologie / Virologie [052]
Descr. géo.OCEAN INDIEN ; LA REUNION ; MAYOTTE
LocalisationFonds IRD [F B010061248]
Identifiant IRDfdi:010061248
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010061248

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