@article{fdi:010061240,
  title = {{P}hytochemical screening and effects on cell-mediated immune response of {P}leurotus fruiting bodies powder},
  author = {{L}laurado, {G}. and {M}orris, {H}. {J}. and {L}ebeque, {Y}. and {G}utierrez, {A}. and {F}ontaine, {R}. and {B}ermudez, {R}. {C}. and {P}erraud {G}aime, {I}sabelle},
  editor = {},
  language = {{ENG}},
  abstract = {{T}his study examined the phytochemical profile and the effects of {P}leurotus fruiting bodies powder on cell-mediated immune response in both in vivo and in vitro assays. {A}lthough carbohydrates (55%, w/w) appear to be the most important immunomodulatory compound, secondary metabolites (terpenoids, phenols and flavonoids) would also enhance immunity. {P}leurotus powder was administered orally during 7 days to {B}alb/c mice (1000 mg/kg) and cyclophosphamide ({CY}; 100 mg/kg) was inoculated intraperitoneally at the beginning of the experiment. {T}he delayed-type hypersensitivity reaction measured at 48 and 72 h after antigen challenge was similar to that of control mice and it was associated with an increase in the mass index of popliteal lymph nodes (p< 0.05). {A}n in vitro lymphoproliferative-stimulating response was also demonstrated with aqueous and ethanolic extracts obtained from {P}leurotus powder. {T}hese effects suggest that {P}leurotus supplement could potentiate the cellular immune response and should be promising for further immunotherapy studies.},
  keywords = {immunomodulating ; mice ; cellular},
  booktitle = {},
  journal = {{F}ood and {A}gricultural {I}mmunology},
  volume = {24},
  numero = {3},
  pages = {295--304},
  ISSN = {0954-0105},
  year = {2013},
  DOI = {10.1080/09540105.2012.686988},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061240},
}