@article{fdi:010061225,
  title = {{E}valuation of trypanocidal drugs used for human {A}frican trypanosomosis against {T}rypanosoma lewisi contre {T}rypanosoma lewisi},
  author = {{D}ethoua, {M}. and {N}zoumbou-{B}oko, {R}. and {T}ruc, {P}hilippe and {D}aulou{\`e}de, {S}. and {C}ourtois, {P}. and {B}ucheton, {B}runo and {C}uny, {G}{\'e}rard and {S}emballa, {S}. and {V}incendeau, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}rypanosomes from animals are potential pathogens for humans. {S}everal human cases infected by {T}ry-panosoma lewisi, a parasite of rats, have been reported. {T}he number of these infections is possibly underestimated. {S}ome infections were self-cured, others required treatment with drugs used in human {A}frican trypanosomosis. {A}n in vitro evaluation of these drugs and fexinidazole, a new oral drug candidate, has been performed against {T}. lewisi in comparison with {T}. brucei gambiense. {A}ll have comparable activities against the two parasites. {S}uramin was not effective. {I}n vivo, drugs were tested in rats immunosuppressed by cyclophosphamide. {T}he best efficacy was obtained for fexinidazole, and pentamidine (15 mg/kg): rats were cured in 7 and 10 days respectively. {R}ats receiving nifurtimoxeflornithine combination therapy ({NECT}) or pentamidine (4 mg/kg) were cured after 28 days, while melarsoprol was weakly active. {T}he identification of efficient drugs with reduced toxicity will help in the management of new cases of atypical trypanosomosis.},
  keywords = {{T}rypanosome ; {T}rypanosoma lewisi ; {T}rypanocidal drugs ; {F}exinidazole ; {A}typical trypanosomiasis ; {AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{P}arasite},
  volume = {20},
  numero = {},
  pages = {39},
  ISSN = {1252-607{X}},
  year = {2013},
  DOI = {10.1051/parasite/2013038},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061225},
}