@article{fdi:010061207, title = {{E}fficacy of {O}lyset ({R}) {P}lus, a new long-lasting insecticidal net incorporating permethrin and piperonil-butoxide against multi-resistant malaria vectors}, author = {{P}ennetier, {C}{\'e}dric and {B}ouraima, {A}. and {C}handre, {F}abrice and {P}iameu, {M}. and {E}tang, {J}. and {R}ossignol, {M}. and {S}idick, {I}. and {Z}ogo, {B}. and {L}acroix, {M}arie-{N}o{\¨e}lle and {Y}adav, {R}. and {P}igeon, {O}. and {C}orbel, {V}incent}, editor = {}, language = {{ENG}}, abstract = {{D}ue to the rapid extension of pyrethroid resistance in malaria vectors worldwide, manufacturers are developing new vector control tools including insecticide mixtures containing at least two active ingredients with different mode of action as part of insecticide resistance management. {O}lyset ({R}) {P}lus is a new long-lasting insecticidal net ({LLIN}) incorporating permethrin and a synergist, piperonyl butoxide ({PBO}), into its fibres in order to counteract metabolic-based pyrethroid resistance of mosquitoes. {I}n this study, we evaluated the efficacy of {O}lyset ({R}) {P}lus both in laboratory and field against susceptible and multi-resistant malaria vectors and compared with {O}lyset ({R}) {N}et, which is a permethrin incorporated into polyethylene net. {I}n laboratory, {O}lyset ({R}) {P}lus performed better than {O}lyset ({R}) {N}et against susceptible {A}nopheles gambiae strain with a 2-day regeneration time owing to an improved permethrin bleeding rate with the new incorporation technology. {I}t also performed better than {O}lyset ({R}) {N}et against multiple resistant populations of {A}n. gambiae in experimental hut trials in {W}est {A}frica. {M}oreover, the present study showed evidence for a benefit of incorporating a synergist, {PBO}, with a pyrethroid insecticide into mosquito netting. {T}hese results need to be further validated in a large-scale field trial to assess the durability and acceptability of this new tool for malaria vector control.}, keywords = {{AFRIQUE} {DE} {L}'{OUEST}}, booktitle = {}, journal = {{P}los {O}ne}, volume = {8}, numero = {10}, pages = {e75134}, ISSN = {1932-6203}, year = {2013}, DOI = {10.1371/journal.pone.0075134}, URL = {https://www.documentation.ird.fr/hor/fdi:010061207}, }