%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Hien, H.
%A Meda, N.
%A Diagbouga, S.
%A Zoure, E.
%A Yameogo, S.
%A Tamboura, H.
%A Some, J.
%A Ouiminga, A.
%A Rouet, F.
%A Drabo, A.
%A Hien, A.
%A Nicolas, J.
%A Chappuy, H.
%A Van de Perre, P.
%A Msellati, Philippe
%A Nacro, B.
%T 24-Month adherence, tolerance and efficacy of once-a-day antiretroviral therapy with didanosine, lamivudine, and efavirenz in African HIV-1 infected children : ANRS 12103/12167
%D 2013
%L fdi:010061199
%G ENG
%J African Health Sciences
%@ 1680-6905
%K once-a-day therapy ; Didanosine ; Lamivudine and Efavirenz ; child
%K BURKINA FASO
%M ISI:000325695600014
%N 2
%P 287-294
%R 10.4314/ahs.v13i2.13
%U https://www.documentation.ird.fr/hor/fdi:010061199
%> https://www.documentation.ird.fr/intranet/publi/2013/11/010061199.pdf
%V 13
%W Horizon (IRD)
%X Background: There is no data on long-term benefit of once-a-day antiretroviral therapy (ART) with combination of DDI, 3TC and EFV to allow its use in future therapeutic strategies. Objectives: To assess 24-month immuno-virological, adherence, tolerance, and effectiveness of a once-a-day ART with DDI, 3TC and EFV. Methods: A phase 2 open trial including 51 children aged from 30 months to 15 years, monitored a once-a-day regimen for 24 months from 2006 to 2008 in the Departement de Pediatrie du CHUSS, at Bobo-Dioulasso in Burkina Faso. We tested immunological and virological response, adherence, tolerance and resistance of the treatment. Results: Children with CD4 > 25% at 24 months were 67.4% (33/49) CI 95% [54%, 80%]. The proportion of children with viral plasma RNA < 300 cp/ml at 24 months of treatment was 81.6 % (40/49) CI [68.0% 91.2%]. Good adherence was obtained with more than 88% adherence > 95% over the 24 months. Drugs were well tolerated. Conclusions: Given the limited number of antiretroviral drugs available in Africa and the inadequacy of laboratory monitoring in support program, once-a-day treatment and especially the DDI-based combination strategies could be an attractive operational option.
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