@article{fdi:010061199,
  title = {24-{M}onth adherence, tolerance and efficacy of once-a-day antiretroviral therapy with didanosine, lamivudine, and efavirenz in {A}frican {HIV}-1 infected children : {ANRS} 12103/12167},
  author = {{H}ien, {H}. and {M}eda, {N}. and {D}iagbouga, {S}. and {Z}oure, {E}. and {Y}ameogo, {S}. and {T}amboura, {H}. and {S}ome, {J}. and {O}uiminga, {A}. and {R}ouet, {F}. and {D}rabo, {A}. and {H}ien, {A}. and {N}icolas, {J}. and {C}happuy, {H}. and {V}an de {P}erre, {P}. and {M}sellati, {P}hilippe and {N}acro, {B}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}here is no data on long-term benefit of once-a-day antiretroviral therapy ({ART}) with combination of {DDI}, 3{TC} and {EFV} to allow its use in future therapeutic strategies. {O}bjectives: {T}o assess 24-month immuno-virological, adherence, tolerance, and effectiveness of a once-a-day {ART} with {DDI}, 3{TC} and {EFV}. {M}ethods: {A} phase 2 open trial including 51 children aged from 30 months to 15 years, monitored a once-a-day regimen for 24 months from 2006 to 2008 in the {D}epartement de {P}ediatrie du {CHUSS}, at {B}obo-{D}ioulasso in {B}urkina {F}aso. {W}e tested immunological and virological response, adherence, tolerance and resistance of the treatment. {R}esults: {C}hildren with {CD}4 > 25% at 24 months were 67.4% (33/49) {CI} 95% [54%, 80%]. {T}he proportion of children with viral plasma {RNA} < 300 cp/ml at 24 months of treatment was 81.6 % (40/49) {CI} [68.0% 91.2%]. {G}ood adherence was obtained with more than 88% adherence > 95% over the 24 months. {D}rugs were well tolerated. {C}onclusions: {G}iven the limited number of antiretroviral drugs available in {A}frica and the inadequacy of laboratory monitoring in support program, once-a-day treatment and especially the {DDI}-based combination strategies could be an attractive operational option.},
  keywords = {once-a-day therapy ; {D}idanosine ; {L}amivudine and {E}favirenz ; child ; {BURKINA} {FASO}},
  booktitle = {},
  journal = {{A}frican {H}ealth {S}ciences},
  volume = {13},
  numero = {2},
  pages = {287--294},
  ISSN = {1680-6905},
  year = {2013},
  DOI = {10.4314/ahs.v13i2.13},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061199},
}