@article{fdi:010061198,
  title = {{I}mpact of repeated ivermectin treatments against onchocerciasis on the transmission of loiasis : an entomologic evaluation in central {C}ameroon},
  author = {{K}ouam, {M}. {K}. and {T}chatchueng-{M}bougua, {J}. {B}. and {D}emanou, {M}. and {B}oussinesq, {M}ichel and {P}ion, {S}{\'e}bastien and {K}amgno, {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {A}nnual community-directed treatment with ivermectin ({CDTI}) have been carried out since 1999 in the {L}ekie division (central region of {C}ameroon where most cases of {L}oa-related post ivermectin severe adverse events were reported) as part of the joined activities of the {A}frican {P}rogramme for {O}nchocerciasis {C}ontrol ({APOC}) and {M}ectizan ({R}) {D}onation {P}rogram ({MDP}). {A}s large-scale administration of ivermetine was demonstrated to be an efficient means to control loiasis transmission, it was hypothesized that {CDTI} would have lowered or halted the transmission of {L}oa loa in the {L}ekie division after 13 years of annual drug administration, indicating a possible reduction in the occurrence of {L}oa-related post-ivermectin severe adverse events. {M}ethods: {A} 4-month entomologic study was carried out from {M}arch to {J}une 2012 in the {L}ekie division to evaluate the impact of 13 years of {CDTI} on the transmission of {L}. loa whose baseline data were recorded in 1999-2000. {R}esults: {T}here was a significant reduction in the infection rate for {C}hrysops silacea and {C}. dimidiata from 6.8 and 9% in 1999-2000 to 3 and 3.6% in 2012, respectively. {T}he differences in the infective rate ({IR}) (percentage of flies harboring head {L}3 larvae), potential infective rate ({PIR}) (percentage of flies bearing {L}3 larvae), mean head {L}3 larvae load ({MHL}3) (average {L}3 per infective fly) and mean fly {L}3 larvae load ({MFL}3) (average {L}3 per potentially infective fly) for both {C}. silacea and {C}. dimidiata were not significantly different between the two investigation periods. {T}he biting density ({BD}) was almost three-fold higher in 2012 for {C}. silacea but not for {C}. dimidiata. {T}he transmission potential ({TP}) which is a function of the {BD}, was higher in the present study than in the baseline investigation for each species. {C}onclusion: {T}he infection rate remaining high, the high {TP} and the stability observed in the {IR}, {PIR}, {MHL}3 and {MFL}3 after 13 years of {CDTI} suggest that transmission of {L}. loa is still active. {T}his is an indication that the risk of occurrence of severe adverse events such as fatal encephalopathies is still present, especially for heavily microfilaria-loaded people taken ivermectin for the first time.},
  keywords = {{CDTI} ; {E}ntomologic indices ; {C}. silacea ; {C}. dimidiata ; {L}oiasis ; {C}ameroon ; {CAMEROUN}},
  booktitle = {},
  journal = {{P}arasites and {V}ectors},
  volume = {6},
  numero = {},
  pages = {283},
  ISSN = {1756-3305},
  year = {2013},
  DOI = {10.1186/1756-3305-6-283},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061198},
}