@article{fdi:010061179,
  title = {{A}nalysis of residual perinatal transmission of hepatitis {B} virus ({HBV}) and of genetic variants in human immunodeficiency virus and {HBV} co-infected women and their offspring},
  author = {{K}hamduang, {W}. and {G}audy-{G}raffin, {C}. and {N}go-{G}iang-{H}uong, {N}icole and {J}ourdain, {G}onzague and {M}oreau, {A}. and {B}orkird, {T}. and {L}ayangool, {P}. and {K}amonpakorn, {N}. and {J}itphiankha, {W}. and {K}wanchaipanich, {R}. and {P}otchalongsin, {S}. and {L}allemant, {M}arc and {S}irirungsi, {W}. and {G}oudeau, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {D}espite implementation of universal infant hepatitis {B} ({HB}) vaccination, mother-to-child transmission ({MTCT}) of hepatitis {B} virus ({HBV}) still occurs. {L}imited data are available on the residual {MTCT} of {HBV} in human immunodeficiency virus ({HIV})-{HBV} co-infected women. {O}bjectives: {W}e assessed the prevalence of {HBV} infection among {HIV}-infected pregnant women and the rate of residual {MTCT} of {HBV} from {HIV}-{HBV} co-infected women and analyzed the viral determinants in mothers and their {HBV}-infected children. {S}tudy design: {HIV}-1 infected pregnant women enrolled in two nationwide perinatal {HIV} prevention trials in {T}hailand were screened for {HB} surface antigen ({HB}s{A}g) and tested for {HB}e{A}g and {HBV} {DNA} load. {I}nfants born to {HB}s{A}g-positive women had {HB}s{A}g and {HBV} {DNA} tested at 4-6 months. {HBV} diversity within each {HBV}-infected mother-infant pair was analyzed by direct sequencing of amplified {HB}s{A}g-encoding gene and cloning of amplified products. {R}esults: {A}mong 3312 {HIV}-1 infected pregnant women, 245(7.4%) were {HB}s{A}g-positive, of whom 125 were {HB}e{A}g-positive. {O}f 230 evaluable infants born to {HB}s{A}g-positive women, 11(4.8%) were found {HB}s{A}g and {HBV} {DNA} positive at 4-6 months; 8 were born to {HB}e{A}g-positive mothers. {HBV} genetic analysis was performed in 9 mother-infant pairs and showed that 5 infants were infected with maternal {HBV} variants harboring mutations within the {HB}s{A}g "a" determinant, and four were infected with wild-type {HBV} present in highly viremic mothers. {C}onclusions: {HBV}-{MTCT} still occurs when women have high {HBV} {DNA} load and/or are infected with {HBV} variants. {A}dditional interventions targeting highly viremic women are thus needed to reduce further {HBV}-{MTCT}.},
  keywords = {{HB}s antigen variants ; {H}epatitis {B} vaccine failure ; {HIV} pregnant women ; {M}other-to-child transmission ; {T}hailand ; {THAILANDE}},
  booktitle = {},
  journal = {{J}ournal of {C}linical {V}irology},
  volume = {58},
  numero = {2},
  pages = {415--421},
  ISSN = {1386-6532},
  year = {2013},
  DOI = {10.1016/j.jcv.2013.06.025},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061179},
}