@article{fdi:010061173,
  title = {{F}irst insights into the cattle serological response to tsetse salivary antigens : a promising direct biomarker of exposure to tsetse bites},
  author = {{S}omda, {M}. {B}. and {B}engaly, {Z}. and {D}ama, {E}. and {P}oinsignon, {A}nne and {D}ayo, {G}. {K}. and {S}idibe, {I}. and {R}emou{\'e}, {F}ranck and {S}anon, {A}. and {B}ucheton, {B}runo},
  editor = {},
  language = {{ENG}},
  abstract = {{I}n the context of the {P}an {A}frican {T}setse and {T}rypanosomiasis {E}radication {C}ampaign, the value of tsetse saliva antibodies as a biomarker of cattle exposure to tsetse flies was evaluated, as this could provide an alternative and complementary tool to conventional entomological methods. {S}erum immune reactivity to {G}lossina ({G}.) palpalis (p.)gambiensis, {G}. tachinoides and {G}. morsitans (m.) submorsitans whole saliva extracts ({WSE}) were monitored in cattle from both tsetse free and tsetse infested areas, and in cows experimentally exposed to tsetse flies and other hematophagous arthropods. {I}n the tsetse infested area, cattle {I}g{G} responses to {G}lossina {WSE} were significantly higher during the dry season (p < 0.0001) when herds are most exposed to tsetse flies and in infected animals (p = 0.01) as expected in the case of a biomarker of exposure. {E}xperimental studies further confirmed this as a quick rise of specific {I}g{G}s was observed in animals exposed to tsetse flies (within weeks), followed by a rapid clearance after exposure was stopped. {I}n contrast to the two other tsetse species, {G}. m. submorsitans {WSE} enabled to detect exposure to all tsetse species and were associated with low level of cross-reactivity to other blood sucking arthropods. {F}inally, {I}g{G} responses to {G}. m. submorsitans salivary antigens enabled to distinguish different groups of cows according to exposure levels, thus indicating that tsetse saliva antibodies are not only indicators of tsetse exposure but also are correlated to the intensity of tsetse contacts (p = 0.0031). {I}mplementation of this new sero-epidemiological marker of cattle exposure to tsetse flies in the framework of tsetse elimination campaigns is discussed.},
  keywords = {{A}frican animal trypanosomosis ; {G}lossina ; {S}aliva ; {A}ntibody ; {B}iomarker of exposure ; {AFRIQUE}},
  booktitle = {},
  journal = {{V}eterinary {P}arasitology},
  volume = {197},
  numero = {1-2},
  pages = {332--340},
  ISSN = {0304-4017},
  year = {2013},
  DOI = {10.1016/j.vetpar.2013.05.018},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061173},
}