Truc Philippe, Buscher P., Cuny Gérard, Gonzatti M. I., Jannin J., Joshi P., Juyal P., Lun Z. R., Mattioli R., Pays E., Simarro P. P., Teixeira M. M. G., Touratier L., Vincendeau P., Desquesnes M. (2013). Atypical human infections by animal trypanosomes. Plos Neglected Tropical Diseases, 7 (9), p. e2256. ISSN 1935-2735.
Titre du document
Atypical human infections by animal trypanosomes
Année de publication
2013
Auteurs
Truc Philippe, Buscher P., Cuny Gérard, Gonzatti M. I., Jannin J., Joshi P., Juyal P., Lun Z. R., Mattioli R., Pays E., Simarro P. P., Teixeira M. M. G., Touratier L., Vincendeau P., Desquesnes M.
Source
Plos Neglected Tropical Diseases, 2013,
7 (9), p. e2256 ISSN 1935-2735
The two classical forms of human trypanosomoses are sleeping sickness due to Trypanosoma brucei gambiense or T. brucei rhodesiense, and Chagas disease due to T. cruzi. However, a number of atypical human infections caused by other T. species (or sub-species) have been reported, namely due to T. brucei brucei, T. vivax, T. congolense, T. evansi, T. lewisi, and T. lewisi-like. These cases are reviewed here. Some infections were transient in nature, while others required treatments that were successful in most cases, although two cases were fatal. A recent case of infection due to T. evansi was related to a lack of apolipoprotein L-I, but T. lewisi infections were not related to immunosuppression or specific human genetic profiles. Out of 19 patients, eight were confirmed between 1974 and 2010, thanks to improved molecular techniques. However, the number of cases of atypical human trypanosomoses might be underestimated. Thus, improvement, evaluation of new diagnostic tests, and field investigations are required for detection and confirmation of these atypical cases.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
;
Sciences du monde animal [080]
Localisation
Fonds IRD [F B010061165]
Identifiant IRD
fdi:010061165
