%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Barea, C.
%A Pabon, A.
%A Perez-Silanes, S.
%A Galiano, S.
%A Gonzalez, G.
%A Monge, A.
%A Deharo, Eric
%A Aldana, I.
%T New amide derivatives of quinoxaline 1,4-di-N-Oxide with leishmanicidal and antiplasmodial activities
%D 2013
%L fdi:010060882
%G ENG
%J Molecules
%@ 1420-3049
%K quinoxaline ; 1,4-di-N-oxide ; leishmanicidal ; antiplasmodial
%M ISI:000318020100073
%N 4
%P 4718-4727
%R 10.3390/molecules18044718
%U https://www.documentation.ird.fr/hor/fdi:010060882
%> https://www.documentation.ird.fr/intranet/publi/2013/06/010060882.pdf
%V 18
%W Horizon (IRD)
%X Malaria and leishmaniasis are two of the World's most important tropical parasitic diseases. Continuing with our efforts to identify new compounds active against malaria and leishmaniasis, twelve new 1,4-di-N-oxide quinoxaline derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum FCR-3 strain, Leishmania infantum and Leishmania amazonensis. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. The results obtained indicate that a cyclopentyl derivative had the best antiplasmodial activity (2.9 mu M), while a cyclohexyl derivative (2.5 mu M) showed the best activity against L. amazonensis, and a 3-chloropropyl derivative (0.7 mu M) showed the best results against L. infantum. All these compounds also have a Cl substituent in the R-7 position.
%$ 052 ; 050 ; 020