@article{fdi:010060882,
  title = {{N}ew amide derivatives of quinoxaline 1,4-di-{N}-{O}xide with leishmanicidal and antiplasmodial activities},
  author = {{B}area, {C}. and {P}abon, {A}. and {P}erez-{S}ilanes, {S}. and {G}aliano, {S}. and {G}onzalez, {G}. and {M}onge, {A}. and {D}eharo, {E}ric and {A}ldana, {I}.},
  editor = {},
  language = {{ENG}},
  abstract = {{M}alaria and leishmaniasis are two of the {W}orld's most important tropical parasitic diseases. {C}ontinuing with our efforts to identify new compounds active against malaria and leishmaniasis, twelve new 1,4-di-{N}-oxide quinoxaline derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against {P}lasmodium falciparum {FCR}-3 strain, {L}eishmania infantum and {L}eishmania amazonensis. {T}heir toxicity against {VERO} cells (normal monkey kidney cells) was also assessed. {T}he results obtained indicate that a cyclopentyl derivative had the best antiplasmodial activity (2.9 mu {M}), while a cyclohexyl derivative (2.5 mu {M}) showed the best activity against {L}. amazonensis, and a 3-chloropropyl derivative (0.7 mu {M}) showed the best results against {L}. infantum. {A}ll these compounds also have a {C}l substituent in the {R}-7 position.},
  keywords = {quinoxaline ; 1,4-di-{N}-oxide ; leishmanicidal ; antiplasmodial},
  booktitle = {},
  journal = {{M}olecules},
  volume = {18},
  numero = {4},
  pages = {4718--4727},
  ISSN = {1420-3049},
  year = {2013},
  DOI = {10.3390/molecules18044718},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060882},
}