@article{fdi:010060854,
  title = {{M}olecular dating of phylogenies by likelihood methods : a comparison of models and a new information criterion},
  author = {{P}aradis, {E}mmanuel},
  editor = {},
  language = {{ENG}},
  abstract = {{D}ating the divergence in a phylogenetic tree is a fundamental step in evolutionary analysis. {S}ome extensions and improvements of the penalised likelihood method originally presented by {S}anderson are introduced. {T}he improvements are the introduction of alternative models, including one with non-correlated rates of molecular substitution ("relaxed" model), a completely reworked fitting algorithm that considers the high-dimensionality of the optimisation problem, and the development of a new information criterion for model selection in the presence of a penalised term. {I}t is also shown that the strict clock model is a special case of the present approach. {A}n extensive simulation study was conducted to assess the statistical performance of these improvements. {O}verall, the different estimators studied here appeared as unbiased though their variance varied depending on the fitted and the simulated models and on the number of calibration points. {T}he strict clock model gave good estimates of branch lengths even in the presence of heterogeneous substitution rates. {T}he correlated model gave the best estimates of substitution rates whatever the model used to simulate the data. {T}hese results, which are certainly the first from an extensive simulation study of a molecular dating method, call for more comparison with alternative methods, as well as further work on the developments introduced here.},
  keywords = {{L}arge-scale estimation ; {M}olecular dating ; {P}enalised likelihood ; {R}ate smoothing ; {R}elaxed molecular clock},
  booktitle = {},
  journal = {{M}olecular {P}hylogenetics and {E}volution},
  volume = {67},
  numero = {2},
  pages = {436--444},
  ISSN = {1055-7903},
  year = {2013},
  DOI = {10.1016/j.ympev.2013.02.008},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060854},
}