%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Sagna, A.B.
%A Sarr, J.B.
%A Gaayeb, L.
%A Dramé, Papa Maktar
%A Ndiath, M.O.
%A Senghor, S.
%A Sow, C. S.
%A Poinsignon, Anne
%A Seck, M.
%A Hermann, E.
%A Schacht, A.M.
%A Faye, N.
%A Sokhna, Cheikh
%A Remoué, Franck
%A Riveau, G.
%T GSG6-P1 salivary biomarker discriminates micro-geographical heterogeneity of human exposure to Anopheles bites in low and seasonal malaria areas
%D 2013
%L fdi:010060845
%G ENG
%J Parasites and Vectors
%@ 1756-3305
%K Malaria ; Salivary peptide ; Biomarker ; Low transmission ; Anopheles exposure ; Antibodies
%K SENEGAL
%M ISI:000317826800001
%P 68
%R 10.1186/1756-3305-6-68
%U https://www.documentation.ird.fr/hor/fdi:010060845
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-10/010060845.pdf
%V 6
%W Horizon (IRD)
%X Background: Over the past decade, a sharp decline of malaria burden has been observed in several countries. Consequently, the conventional entomological methods have become insufficiently sensitive and probably underestimate micro-geographical heterogeneity of exposure and subsequent risk of malaria transmission. In this study, we investigated whether the human antibody (Ab) response to Anopheles salivary gSG6-P1 peptide, known as a biomarker of Anopheles exposure, could be a sensitive and reliable tool for discriminating human exposure to Anopheles bites in area of low and seasonal malaria transmission. Methods: A multi-disciplinary survey was performed in Northern Senegal where An. gambiae s.l. is the main malaria vector. Human IgG Ab response to gSG6-P1 salivary peptide was compared according to the season and villages in children from five villages in the middle Senegal River valley, known as a low malaria transmission area. Results: IgG levels to gSG6-P1 varied considerably according to the villages, discriminating the heterogeneity of Anopheles exposure between villages. Significant increase of IgG levels to gSG6-P1 was observed during the peak of exposure to Anopheles bites, and decreased immediately after the end of the exposure season. In addition, differences in the season-dependent specific IgG levels between villages were observed after the implementation of Long-Lasting Insecticidal Nets by The National Malaria Control Program in this area. Conclusion: The gSG6-P1 salivary peptide seems to be a reliable tool to discriminate the micro-geographical heterogeneity of human exposure to Anopheles bites in areas of very low and seasonal malaria transmission. A biomarker such as this could also be used to monitor and evaluate the possible heterogeneous effectiveness of operational vector control programs in low-exposure areas.
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