@article{fdi:010060797,
  title = {{E}ffects of pyrethroid resistance on the cost effectiveness of a mass distribution of long-lasting insecticidal nets : a modelling study},
  author = {{B}riet, {O}. {J}. {T}. and {P}enny, {M}. {A}. and {H}ardy, {D}. and {A}wolola, {T}. {S}. and {V}an {B}ortel, {W}. and {C}orbel, {V}incent and {D}abir{\'e}, {R}. {K}. and {E}tang, {J}. and {K}oudou, {B}. {G}. and {T}ungu, {P}. {K}. and {C}hitnis, {N}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}he effectiveness of insecticide-treated nets in preventing malaria is threatened by developing resistance against pyrethroids. {L}ittle is known about how strongly this affects the effectiveness of vector control programmes. {M}ethods: {D}ata from experimental hut studies on the effects of long-lasting, insecticidal nets ({LLIN}s) on nine anopheline mosquito populations, with varying levels of mortality in {W}orld {H}ealth {O}rganization susceptibility tests, were used to parameterize malaria models. {B}oth simple static models predicting population-level insecticidal effectiveness and protection against blood feeding, and complex dynamic epidemiological models, where {LLIN}s decayed over time, were used. {T}he epidemiological models, implemented in {O}pen{M}alaria, were employed to study the impact of a single mass distribution of {LLIN}s on malaria, both in terms of episodes prevented during the effective lifetime of the batch of {LLIN}s, and in terms of net health benefits ({NHB}) expressed in disability-adjusted life years ({DALY}s) averted during that period, depending on net type (standard pyrethroid-only {LLIN} or pyrethroid-piperonyl butoxide combination {LLIN}), resistance status, coverage and pre-intervention transmission level. {R}esults: {T}here were strong positive correlations between insecticide susceptibility status and predicted population level insecticidal effectiveness of and protection against blood feeding by {LLIN} intervention programmes. {W}ith the most resistant mosquito population, the {LLIN} mass distribution averted up to about 40% fewer episodes and {DALY}s during the effective lifetime of the batch than with fully susceptible populations. {H}owever, cost effectiveness of {LLIN}s was more sensitive to the pre-intervention transmission level and coverage than to susceptibility status. {F}or four out of the six {A}nopheles gambiae sensu lato populations where direct comparisons between standard {LLIN}s and combination {LLIN}s were possible, combination nets were more cost effective, despite being more expensive. {W}ith one resistant population, both net types were equally effective, and with one of the two susceptible populations, standard {LLIN}s were more cost effective. {C}onclusion: {D}espite being less effective when compared to areas with susceptible mosquito populations, standard and combination {LLIN}s are likely to (still) be cost effective against malaria even in areas with strong pyrethroid resistance. {C}ombination nets are likely to be more cost effective than standard nets in areas with resistant mosquito populations.},
  keywords = {{P}yrethroid ; {I}nsecticide ; {R}esistance ; {LLIN} ; {ITN} ; {M}odelling ; {P}iperonyl ; butoxide},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {12},
  numero = {},
  pages = {77},
  ISSN = {1475-2875},
  year = {2013},
  DOI = {10.1186/1475-2875-12-77},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060797},
}