@article{fdi:010060790,
  title = {{A}ntimicrobial resistance in invasive non-typhoid {S}almonella from the {D}emocratic {R}epublic of the {C}ongo : emergence of decreased fluoroquinolone susceptibility and extended-spectrum beta lactamases},
  author = {{L}unguya, {O}. and {L}ejon, {V}eerle and {P}hoba, {M}. {F}. and {B}ertrand, {S}ophie and {V}anhoof, {R}. and {G}lupczynski, {Y}. and {V}erhaegen, {J}. and {M}uyembe-{T}amfum, {J}. {J}. and {J}acobs, {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {C}o-resistance against the first-line antibiotics ampicillin, chloramphenicol and trimethoprim/sulphamethoxazole or multidrug resistance ({MDR}) is common in non typhoid {S}almonella ({NTS}). {U}se of alternative antibiotics, such as fluoroquinolones or third generation cephalosporins is threatened by increasing resistance, but remains poorly documented in {C}entral-{A}frica. {M}ethodology/{P}rincipal findings: {A}s part of a microbiological surveillance study in {DR} {C}ongo, blood cultures were collected between 2007 and 2011. {I}solated {NTS} were assessed for serotype and antimicrobial resistance including decreased ciprofloxacin susceptibility and extended-spectrum beta-lactamase ({ESBL}) production. {I}n total, 233 {NTS} isolates (representing 23.6% of clinically significant organisms) were collected, mainly consisting of {S}almonella {T}yphimurium (79%) and {S}almonella {E}nteritidis (18%). {T}he majority of {NTS} were isolated in the rainy season, and recovered from children <= 2 years old. {MDR}, decreased ciprofloxacin susceptibility, azithromycin and cefotaxime resistance were 80.7%, 4.3%, 3.0% and 2.1% respectively. {ESBL} production was noted in three (1.3%) isolates. {D}ecreased ciprofloxacin susceptibility was associated with mutations in codon 87 of the gyr{A} gene, while {ESBL}s all belonged to the {SHV}-2a type. {C}onclusions/{S}ignificance: {P}resence of almost full {MDR} among {NTS} isolates from blood cultures in {C}entral {A}frica was confirmed. {R}esistance to fluoroquinolones, azithromycin and third generation cephalosporins is still low, but emerging. {I}ncreased microbiological surveillance in {DR} {C}ongo is crucial for adapted antibiotic therapy and the development of treatment guidelines.},
  keywords = {{REPUBLIQUE} {DEMOCRATIQUE} {DU} {CONGO}},
  booktitle = {},
  journal = {{P}los {N}eglected {T}ropical {D}iseases},
  volume = {7},
  numero = {3},
  pages = {e2103},
  ISSN = {1935-2735},
  year = {2013},
  DOI = {10.1371/journal.pntd.0002103},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060790},
}