@article{fdi:010060781,
  title = {{P}redictive factors of plasma {HIV} suppression during pregnancy : a prospective cohort study in {B}enin},
  author = {{D}enoeud {N}dam, {L}ise and {F}ourcade, {C}. and {O}gouyemi-{H}ounto, {A}. and {A}zon-{K}ouanou, {A}. and d'{A}lmeida, {M}. and {A}zondekon, {A}. and {A}lao, {M}. {J}. and {D}ossou-{G}bete, {V}. and {A}fangnihoun, {A}. and {G}irard, {P}. {M}. and {C}ot, {M}ichel and {Z}annou, {D}. {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjective: {T}o investigate the factors associated with {HIV}1 {RNA} plasma viral load (p{VL}) below 40 copies/m{L} at the third trimester of pregnancy, as part of prevention of mother-to-child transmission ({PMTCT}) in {B}enin. {D}esign: {S}ub study of the {PACOME} clinical trial of malaria prophylaxis in {HIV}-infected pregnant women, conducted before and after the implementation of the {WHO} 2009 revised guidelines for {PMTCT}. {M}ethods: {HIV}-infected women were enrolled in the second trimester of pregnancy. {S}ocio-economic characteristics, {HIV} history, clinical and biological characteristics were recorded. {M}alaria prevention and {PMTCT} involving antiretroviral therapy ({ART}) for mothers and infants were provided. {L}ogistic regression helped identifying factors associated with virologic suppression at the end of pregnancy. {R}esults: {O}verall 217 third trimester p{VL}s were available, and 71% showed undetectability. {V}irologic suppression was more frequent in women enrolled after the change in {PMTCT} recommendations, advising to start {ART} at 14 weeks instead of 28 weeks of pregnancy. {I}n multivariate analysis, {F}on ethnic group (the predominant ethnic group in the study area), regular job, first and second pregnancy, higher baseline p{VL} and impaired adherence to {ART} were negative factors whereas higher weight, higher antenatal care attendance and longer {ART} duration were favorable factors to achieve virologic suppression. {C}onclusions: {T}his study provides more evidence that {ART} has to be initiated before the last trimester of pregnancy to achieve an undetectable p{VL} before delivery. {I}n {B}enin, new recommendations supporting early initiation were well implemented and, together with a high antenatal care attendance, led to high rate of virologic control.},
  keywords = {{BENIN}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {8},
  numero = {3},
  pages = {e59446},
  ISSN = {1932-6203},
  year = {2013},
  DOI = {10.1371/journal.pone.0059446},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060781},
}