@article{fdi:010060757,
  title = {{F}lavodiiron proteins {F}lv1 and {F}lv3 enable cyanobacterial growth and photosynthesis under fluctuating light},
  author = {{A}llahverdiyeva, {Y}. and {M}ustila, {H}. and {E}rmakova, {M}. and {B}ersanini, {L}. and {R}ichaud, {P}. and {A}jlani, {G}. and {B}attchikova, {N}. and {C}ournac, {L}aurent and {A}ro, {E}. {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}yanobacterial flavodiiron proteins ({FDP}s; {A}-type flavoprotein, {F}lv) comprise, besides the beta-lactamase-like and flavodoxin domains typical for all {FDP}s, an extra {NAD}({P}){H}:flavin oxidoreductase module and thus differ from {FDP}s in other {B}acteria and {A}rchaea. {S}ynechocystis sp. {PCC} 6803 has four genes encoding the {FDP}s. {F}lv1 and {F}lv3 function as an {NAD}({P}) {H}: oxygen oxidoreductase, donating electrons directly to {O}-2 without production of reactive oxygen species. {H}ere we show that the {F}lv1 and {F}lv3 proteins are crucial for cyanobacteria under fluctuating light, a typical light condition in aquatic environments. {U}nder constant-light conditions, regardless of light intensity, the {F}lv1 and {F}lv3 proteins are dispensable. {I}n contrast, under fluctuating light conditions, the growth and photosynthesis of the {D}elta flv1({A}) and/or {D}elta flv3({A}) mutants of {S}ynechocystis sp. {PCC} 6803 and {A}nabaena sp. {PCC} 7120 become arrested, resulting in cell death in the most severe cases. {T}his reaction is mainly caused by malfunction of photosystem {I} and oxidative damage induced by reactive oxygen species generated during abrupt short-term increases in light intensity. {U}nlike higher plants that lack the {FDP}s and use the {P}roton {G}radient {R}egulation 5 to safeguard photosystem {I}, the cyanobacterial homolog of {P}roton {G}radient {R}egulation 5 is shown not to be crucial for growth under fluctuating light. {I}nstead, the unique {F}lv1/{F}lv3 heterodimer maintains the redox balance of the electron transfer chain in cyanobacteria and provides protection for photosystem {I} under fluctuating growth light. {E}volution of unique cyanobacterial {FDP}s is discussed as a prerequisite for the development of oxygenic photosynthesis.},
  keywords = {{M}ehler reaction ; membrane inlet mass spectrometry ; photorespiration ; terminal oxidases},
  booktitle = {},
  journal = {{P}roceedings of the {N}ational {A}cademy of {S}ciences of the {U}nited {S}tates of {A}merica},
  volume = {110},
  numero = {10},
  pages = {4111--4116},
  ISSN = {0027-8424},
  year = {2013},
  DOI = {10.1073/pnas.1221194110},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060757},
}