Publications des scientifiques de l'IRD

Loucoubar C., Grange L., Paul R., Huret A., Tall A., Telle O., Roussilhon C., Faye J., Diene-Sarr F., Trape Jean-François, Mercereau-Puijalon O., Sakuntabhai A., Bureau J. F. (2013). High number of previous Plasmodium falciparum clinical episodes increases risk of future episodes in a sub-group of individuals. Plos One, 8 (2), p. e55666. ISSN 1932-6203.

Titre du document
High number of previous Plasmodium falciparum clinical episodes increases risk of future episodes in a sub-group of individuals
Année de publication
2013
Type de document
Article référencé dans le Web of Science WOS:000315153400136
Auteurs
Loucoubar C., Grange L., Paul R., Huret A., Tall A., Telle O., Roussilhon C., Faye J., Diene-Sarr F., Trape Jean-François, Mercereau-Puijalon O., Sakuntabhai A., Bureau J. F.
Source
Plos One, 2013, 8 (2), p. e55666 ISSN 1932-6203
There exists great disparity in the number of clinical P. falciparum episodes among children of the same age and living in similar conditions. The epidemiological determinants of such disparity are unclear. We used a data-mining approach to explore a nineteen-year longitudinal malaria cohort study dataset from Senegal and identify variables associated with increased risk of malaria episodes. These were then verified using classical statistics and replicated in a second cohort. In addition to age, we identified a novel high-risk group of children in whom the history of P. falciparum clinical episodes greatly increased risk of further episodes. Age and a high number of previous falciparum clinical episodes not only play major roles in explaining the risk of P. falciparum episodes but also are risk factors for different groups of people. Combined, they explain the majority of falciparum clinical attacks. Contrary to what is widely believed, clinical immunity to P. falciparum does not de facto occur following many P. falciparum clinical episodes. There exist a sub-group of children who suffer repeated clinical episodes. In addition to posing an important challenge for population stratification during clinical trials, this sub-group disproportionally contributes to the disease burden and may necessitate specific prevention and control measures.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
SENEGAL
Localisation
Fonds IRD [F B010060710]
Identifiant IRD
fdi:010060710
Contact