@article{fdi:010060692,
  title = {{P}lasmodium falciparum variability and immune evasion proceed from antigenicity of consensus sequences from {DBL}6 epsilon ; generalization to {A}ll {DBL} from {VAR}2{CSA}},
  author = {{D}eloron, {P}hilippe and {M}ilet, {J}acqueline and {B}adaut, {C}yril},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e studied all consensus sequences within the four least 'variable blocks' ({VB}) present in the {DBL}6 epsilon domain of {VAR}2{CSA}, the protein involved in the adhesion of infected red blood cells by {P}lasmodium falciparum that causes the {P}regnancy-{A}ssociated {M}alaria ({PAM}). {C}haracterising consensus sequences with respect to recognition of antibodies and percentage of responders among pregnant women living in areas where {P}. falciparum is endemic allows the identification of the most antigenic sequences within each {VB}. {W}hen combining these consensus sequences among four serotypes from {VB}1 or {VB}5, the most often recognized ones are expected to induce pan-reactive antibodies recognizing {VAR}2{CSA} from all plasmodial strains. {T}hese sequences are of main interest in the design of an immunogenic molecule. {U}sing a similar approach than for {DBL}6e, we studied the five other {DBL} and the {CIDR}pam from {VAR}2{CSA}, and again identified {VB} segments with highly conserved consensus sequences. {I}n addition, we identified consensus sequences in other var genes expressed by non-{PAM} parasites. {T}his finding paves the way for vaccine design against other pathologies caused by {P}. falciparum.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {8},
  numero = {1},
  pages = {e54882},
  ISSN = {1932-6203},
  year = {2013},
  DOI = {10.1371/journal.pone.0054882},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060692},
}