@article{fdi:010060650,
  title = {{A}pplication of a selective extraction method for methylmercury compound specific stable isotope analysis ({M}e{H}g-{CSIA}) in biological materials},
  author = {{M}asbou, {J}. and {P}oint, {D}avid and {S}onke, {J}. {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{M}ethylmercury ({M}e{H}g) is a key organometallic compound of {H}g and a potent neurotoxin that bioaccumulates along food webs. {H}g speciation analysis of environmental samples is essential for understanding the sources, dynamics and impact of {M}e{H}g in ecosystems. {H}g stable isotope analysis is a new tool to try and answer outstanding questions on {H}g cycling, but has thus far been applied essentially to total {H}g fractions in biota. {H}g compound specific stable isotope analysis is a new approach to understand the isotopic fraction of {H}g at the molecular level. {I}n this study, we developed a robust, accurate and precise selective extraction method for {M}e{H}g in biological samples for subsequent quantification by {AFS} or {ID}-{GC}-{ICPMS} and determination of the isotopic composition by {CV}-{MC}-{ICPMS}. {T}he method consists of an optimized two-step extraction/back-extraction technique validated using a {M}e{H}g standard solution and seven certified reference materials with a large range of total {H}g and {M}e{H}g values. {I}n the final extract solution, {M}e{H}g purification yields were higher than 97%, and accurate {M}e{H}g concentrations were obtained for the different certified materials. {H}igh precision {M}e{H}g stable isotope analysis (2{SD} approximate to 0.1 parts per thousand) by {CV}-{MC}-{ICPMS} showed a four-fold improvement in precision for this method relative to previous on-line {GC}-{MC}-{ICPMS} measurements. {R}eference values for total {H}g and {M}e{H}g compound specific stable isotope values are given for {NRCC}-{TORT}-2, {NRCC}-{DOLT}-4, {IRMM}-{ERM}-{CE}464, {IRMM}-{BCR}-463, {IRMM}-{BCR}-414, {NIST}-{SRM}-1947 and {NIST}-{QC}03{LH}03 reference materials.},
  keywords = {},
  booktitle = {},
  journal = {{J}ournal of {A}nalytical {A}tomic {S}pectrometry},
  volume = {28},
  numero = {10},
  pages = {1620--1628},
  ISSN = {0267-9477},
  year = {2013},
  DOI = {10.1039/c3ja50185j},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060650},
}