@article{fdi:010060608,
  title = {{U}se of a colorimetric ({DELI}) test for the evaluation of chemoresistance of {P}lasmodium falciparum and {P}lasmodium vivax to commonly used anti-plasmodial drugs in the {B}razilian {A}mazon},
  author = {{P}ratt-{R}iccio, {L}. {R}. and {C}hehuan, {Y}. {F}. and {S}iqueira, {M}. {J}. and {A}lecrim, {M}. {G}. and {B}ianco, {C}. and {D}ruilhe, {P}. and {B}rasseur, {P}hilippe and {F}erreira-{D}a-{C}ruz, {M}. {F}. and {C}arvalho, {L}. {J}. {M}. and {D}aniel-{R}ibeiro, {C}. {T}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}he emergence and spread of {P}lasmodium falciparum and {P}lasmodium vivax resistance to available anti-malarial drugs represents a major drawback in the control of malaria and its associated morbidity and mortality. {T}he aim of this study was to evaluate the chemoresistance profile of {P}. falciparum and {P}. vivax to commonly used anti-plasmodial drugs in a malaria-endemic area in the {B}razilian {A}mazon. {M}ethods: {T}he study was carried out in {M}anaus ({A}mazonas state), in the {B}razilian {A}mazon. {A} total of 88 {P}. falciparum and 178 {P}. vivax isolates was collected from 2004 to 2007. {T}he sensitivity of {P}. falciparum isolates was determined to chloroquine, quinine, mefloquine and artesunate and the sensitivity of {P}. vivax isolates was determined to chloroquine and mefloquine, by using the colorimetric {DELI} test. {R}esults: {A}s expected, a high prevalence of {P}. falciparum isolates resistant to chloroquine (78.1%) was observed. {T}he prevalence of isolates with profile of resistance or decreased sensitivity for quinine, mefloquine and artesunate was 12.7, 21.2 and 11.7%, respectively. {I}n the case of {P}. vivax, the prevalence of isolates with profile of resistance for chloroquine and mefloquine was 9.8 and 28%, respectively. {N}o differences in the frequencies of isolates with profile of resistance or geometric mean {IC}50s were seen when comparing the data obtained in 2004, 2005, 2006 and 2007, for all tested anti-malarials. {C}onclusions: {T}he great majority of {P}. falciparum isolates in the {B}razilian malaria-endemic area remain resistant to chloroquine, and the decreased sensitivity to quinine, mefloquine and artesunate observed in 10-20% of the isolates must be taken with concern, especially for artesunate. {P}lasmodium vivax isolates also showed a significant proportion of isolates with decreased sensitivity to chloroquine (first-line drug) and mainly to mefloquine. {T}he data presented here also confirm the usefulness of the {DELI} test to generate results able to impact on public health policies.},
  keywords = {{M}alaria ; {P}lasmodium falciparum ; {P}lasmodium vivax ; {R}esistance ; {A}nti-malarials ; {DELI} test ; {BRESIL} ; {AMZONIE}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {12},
  numero = {},
  pages = {294},
  ISSN = {1475-2875},
  year = {2013},
  DOI = {10.1186/1475-2875-12-281},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060608},
}