@article{fdi:010060607,
  title = {{A}ssessment of iron deficiency in the context of the obesity epidemic : importance of correcting serum ferritin concentrations for inflammation},
  author = {{G}artner, {A}gn{\`e}s and {B}erger, {J}acques and {B}our, {A}. and {E}l {A}ti, {J}. and {T}raissac, {P}ierre and {L}andais, {E}dwige and {E}l {K}abbaj, {S}. and {D}elpeuch, {F}rancis},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}he correction of serum ferritin ({SF}) concentrations for inflammation because of infectious or parasitic diseases was recently proposed, especially in developing countries, but in many countries, adiposity has become the main cause of inflammation {O}bjective: {W}e assessed, overall and by adiposity status, the bias in the estimation of iron deficiency ({ID}) on the basis of uncorrected {SF}. {D}esign: {A} cross-sectional survey in 2010 in {R}abat-{S}ale, {M}orocco, used a random sample of 811 women aged 20-49 y. {A}diposity was assessed by body mass index ({BMI}) (in kg/m(2)) (normal: {BMI} <25; overweight: {BMI} >= 25 to <30; obese: {BMI} >= 30), waist circumference, and body fat. {I}nflammation was indicated by a {C}-reactive protein ({CRP}) concentration >2 mg/{L}. {ID} was indicated by an {SF} concentration <15 mu g/{L}. {T}he correction factor of {SF} for inflammation was derived from our sample. {D}ifferential effects of {SF} correction on {ID} status on the basis of adiposity were assessed by models that included adiposity {X} correction interactions and accounted for the within-subject correlation. {R}esults: {T}he prevalence of overweight was 33.0% and of obesity was 34.0%. {I}nflammation (42.3%) was strongly linked with adiposity (20.1%, 37.6%, and 68.4% in normal, overweight, and obese subjects, respectively; {P} < 0.0001). {SF} increased from a {CRP} concentration >2 mg/{L}. {T}he correction factor of {SF} was 0.65. {T}he prevalence of {ID} (37.2% compared with 45.2%; difference -8.0%, {P} < 0.0001) was underestimated by not correcting {SF}, and the difference increased with adiposity (-2.9%, -8.5%, and -12.4% in normal, overweight, and obese subjects, respectively; {P}-interaction < 0.0001). {A}nalogous results were observed for other adiposity measures. {C}onclusion: {I}n developing countries where {ID} remains prevalent but rates of obesity are already high, corrected {SF} should be used when assessing {ID} status, even if infectious or parasitic diseases are no longer widespread. {T}his trial was registered at clinicaltrials.gov as {NCT}01844349.},
  keywords = {},
  booktitle = {},
  journal = {{A}merican {J}ournal of {C}linical {N}utrition},
  volume = {98},
  numero = {3},
  pages = {821--826},
  ISSN = {0002-9165},
  year = {2013},
  DOI = {10.3945/ajcn.112.054551},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060607},
}