@article{fdi:010060599,
  title = {{D}ietary intervention impact on gut microbial gene richness},
  author = {{C}otillard, {A}. and {K}ennedy, {S}. {P}. and {K}ong, {L}. {C}. and {P}rifti, {E}. and {P}ons, {N}. and {L}e {C}hatelier, {E}. and {A}lmeida, {M}. and {Q}uinquis, {B}. and {L}evenez, {F}. and {G}alleron, {N}. and {G}ougis, {S}. and {R}izkalla, {S}. and {B}atto, {J}. {M}. and {R}enault, {P}. and {D}ore, {J}. and {Z}ucker, {J}ean-{D}aniel and {C}lement, {K}. and {E}hrlich, {S}. {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}omplex gene-environment interactions are considered important in the development of obesity(1). {T}he composition of the gut microbiota can determine the efficacy of energy harvest from food(2-4) and changes in dietary composition have been associated with changes in the composition of gut microbial populations(5,6). {T}he capacity to explore microbiota composition was markedly improved by the development of metagenomic approaches(7,8), which have already allowed production of the first human gut microbial gene catalogue(9) and stratifying individuals by their gut genomic profile into different enterotypes(10), but the analyses were carried out mainly in nonintervention settings. {T}o investigate the temporal relationships between food intake, gut microbiota and metabolic and inflammatory phenotypes, we conducted diet-induced weight-loss and weight-stabilization interventions in a study sample of 38 obese and 11 overweight individuals. {H}ere we report that individuals with reduced microbial gene richness (40%) present more pronounced dys-metabolism and low-grade inflammation, as observed concomitantly in the accompanying paper(11). {D}ietary intervention improves low gene richness and clinical phenotypes, but seems to be less efficient for inflammation variables in individuals with lower gene richness. {L}ow gene richness may therefore have predictive potential for the efficacy of intervention.},
  keywords = {},
  booktitle = {},
  journal = {{N}ature},
  volume = {500},
  numero = {7464},
  pages = {585--588 + 2},
  ISSN = {0028-0836},
  year = {2013},
  DOI = {10.1038/nature12480},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060599},
}