@article{fdi:010060586,
  title = {{T}he {T}rypanosoma brucei gambiense secretome impairs lipopolysaccharide-induced maturation, cytokine production, and allostimulatory capacity of dendritic cells},
  author = {{G}arzon, {E}. and {H}olzmuller, {P}. and {B}ras {G}oncalves, {R}achel and {V}incendeau, {P}. and {C}uny, {G}{\'e}rard and {L}emesre, {J}ean-{L}oup and {G}eiger, {A}nne},
  editor = {},
  language = {{ENG}},
  abstract = {{T}rypanosoma brucei gambiense, a parasitic protozoan belonging to kinetoplastids, is the main etiological agent of human {A}frican trypanosomiasis ({HAT}), or sleeping sickness. {O}ne major characteristic of this disease is the dysregulation of the host immune system. {T}he present study demonstrates that the secretome (excreted-secreted proteins) of {T}. b. gambiense impairs the lipopolysaccharide ({LPS})-induced maturation of murine dendritic cells ({DC}s). {T}he upregulation of major histocompatibility complex class {II}, {CD}40, {CD}80, and {CD}86 molecules, as well as the secretion of cytokines such as tumor necrosis factor alpha, interleukin-10 ({IL}-10), and {IL}-6, which are normally released at high levels by {LPS}-stimulated {DC}s, is significantly reduced when these cells are cultured in the presence of the {T}. b. gambiense secretome. {M}oreover, the inhibition of {DC} maturation results in the loss of their allostimulatory capacity, leading to a dramatic decrease in {T}h1/{T}h2 cytokine production by cocultured lymphocytes. {T}hese results provide new insights into a novel efficient immunosuppressive mechanism directly involving the alteration of {DC} function which might be used by {T}. b. gambiense to interfere with the host immune responses in {HAT} and promote the infectious process.},
  keywords = {{AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{I}nfection and {I}mmunity},
  volume = {81},
  numero = {9},
  pages = {3300--3308},
  ISSN = {0019-9567},
  year = {2013},
  DOI = {10.1128/iai.00125-13},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060586},
}