@article{fdi:010060576,
  title = {{F}ast and easy extraction combined with high resolution-mass spectrometry for residue analysis of two anticonvulsants and their transformation products in marine mussels},
  author = {{B}ueno, {M}. {J}. {M}. and {B}oillot, {C}. and {F}enet, {H}. and {C}hiron, {S}erge and {C}asellas, {C}. and {G}omez, {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{E}nvironmental field studies have shown that carbamazepine ({C}bz) is one of the most frequently detected human pharmaceuticals in different aquatic compartments. {H}owever, little data is available on the detection of this substance and its transformation products in aquatic organisms. {T}his study was thus mainly carried out to optimize and validate a simple and sensitive analytical methodology for the detection, characterization and quantification of {C}bz and oxcarbazepine ({O}x), two anticonvulsants, and six of their main transformation products in marine mussels ({M}ytilus galloprovincialis). {A} modified {Q}u{EC}h{ERS} extraction method followed by analysis with liquid chromatography coupled to high resolution mass spectrometry ({HRMS}) was used. {T}he analyses were performed using two-stage fragmentation to reveal the different fragmentation pathways that are highly useful for the identification of isomeric compounds, a common problem when several transformation products are analyzed. {T}he developed analytical method allowed determination of the target analytes in the lower ng/g concentration levels. {T}he mean recovery ranged from 67 to 110%. {T}he relative standard deviation was under 11% in the intra-day and 18% in the interday analyses, respectively. {F}inally, the method was applied to marine mussel samples collected from {M}editerranean {S}ea cultures in southeastern {F}rance. {R}esidues of the psychiatric drug {C}bz were occasionally found at levels up to 3.5 ng/g dw. {L}astly, in this study, other non-target compounds, such as caffeine, metoprolol, cotinine and ketoprofen, were identified in the real samples analyzed.},
  keywords = {{P}harmaceuticals ; {M}arine environment ; {A}quatic organisms ; {B}iota ; {Q}u{EC}h{ERS} ; {M}etabolites ; {FRANCE} ; {MER} {MEDITERRANEE}},
  booktitle = {},
  journal = {{J}ournal of {C}hromatography {A}},
  volume = {1305},
  numero = {},
  pages = {27--34},
  ISSN = {0021-9673},
  year = {2013},
  DOI = {10.1016/j.chroma.2013.06.071},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060576},
}