Publications des scientifiques de l'IRD

Bueno M. J. M., Boillot C., Fenet H., Chiron Serge, Casellas C., Gomez E. (2013). Fast and easy extraction combined with high resolution-mass spectrometry for residue analysis of two anticonvulsants and their transformation products in marine mussels. Journal of Chromatography A, 1305, p. 27-34. ISSN 0021-9673.

Titre du document
Fast and easy extraction combined with high resolution-mass spectrometry for residue analysis of two anticonvulsants and their transformation products in marine mussels
Année de publication
2013
Type de document
Article référencé dans le Web of Science WOS:000323362200004
Auteurs
Bueno M. J. M., Boillot C., Fenet H., Chiron Serge, Casellas C., Gomez E.
Source
Journal of Chromatography A, 2013, 1305, p. 27-34 ISSN 0021-9673
Environmental field studies have shown that carbamazepine (Cbz) is one of the most frequently detected human pharmaceuticals in different aquatic compartments. However, little data is available on the detection of this substance and its transformation products in aquatic organisms. This study was thus mainly carried out to optimize and validate a simple and sensitive analytical methodology for the detection, characterization and quantification of Cbz and oxcarbazepine (Ox), two anticonvulsants, and six of their main transformation products in marine mussels (Mytilus galloprovincialis). A modified QuEChERS extraction method followed by analysis with liquid chromatography coupled to high resolution mass spectrometry (HRMS) was used. The analyses were performed using two-stage fragmentation to reveal the different fragmentation pathways that are highly useful for the identification of isomeric compounds, a common problem when several transformation products are analyzed. The developed analytical method allowed determination of the target analytes in the lower ng/g concentration levels. The mean recovery ranged from 67 to 110%. The relative standard deviation was under 11% in the intra-day and 18% in the interday analyses, respectively. Finally, the method was applied to marine mussel samples collected from Mediterranean Sea cultures in southeastern France. Residues of the psychiatric drug Cbz were occasionally found at levels up to 3.5 ng/g dw. Lastly, in this study, other non-target compounds, such as caffeine, metoprolol, cotinine and ketoprofen, were identified in the real samples analyzed.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020] ; Pollution [038]
Description Géographique
FRANCE ; MER MEDITERRANEE
Localisation
Fonds IRD [F B010060576]
Identifiant IRD
fdi:010060576
Contact