@article{fdi:010060573,
  title = {{P}atterns of nucleotide and haplotype diversity at {ICAM}-1 across global human populations with varying levels of malaria exposure},
  author = {{G}omez, {F}. and {T}omas, {G}. and {K}o, {W}. {Y}. and {R}anciaro, {A}. and {F}roment, {A}lain and {I}brahim, {M}. and {L}ema, {G}. and {N}yambo, {T}. {B}. and {O}mar, {S}. {A}. and {W}ambebe, {C}. and {H}irbo, {J}. {B}. and {R}ocha, {J}. and {T}ishkoff, {S}. {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{M}alaria is one of the strongest selective pressures in recent human evolution. {A}frican populations have been and continue to be at risk for malarial infections. {H}owever, few studies have re-sequenced malaria susceptibility loci across geographically and genetically diverse groups in {A}frica. {W}e examined nucleotide diversity at {I}ntercellular adhesion molecule-1 ({ICAM}-1), a malaria susceptibility candidate locus, in a number of human populations with a specific focus on diverse {A}frican ethnic groups. {W}e used tests of neutrality to assess whether natural selection has impacted this locus and tested whether {SNP} variation at {ICAM}-1 is correlated with malaria endemicity. {W}e observe differing patterns of nucleotide and haplotype variation in global populations and higher levels of diversity in {A}frica. {A}lthough we do not observe a deviation from neutrality based on the allele frequency distribution, we do observe several alleles at {ICAM}-1, including the {ICAM}-1 ({K}ilifi) allele, that are correlated with malaria endemicity. {W}e show that the {ICAM}-1 ({K}ilifi) allele, which is common in {A}frica and {A}sia, exists on distinct haplotype backgrounds and is likely to have arisen more recently in {A}sia. {O}ur results suggest that correlation analyses of allele frequencies and malaria endemicity may be useful for identifying candidate functional variants that play a role in malaria resistance and susceptibility.},
  keywords = {{AFRIQUE} ; {ASIE}},
  booktitle = {},
  journal = {{H}uman {G}enetics},
  volume = {132},
  numero = {9},
  pages = {987--999},
  ISSN = {0340-6717},
  year = {2013},
  DOI = {10.1007/s00439-013-1284-5},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060573},
}