@article{fdi:010060475,
  title = {{G}ut microbiota after gastric bypass in human obesity : increased richness and associations of bacterial genera with adipose tissue genes},
  author = {{K}ong, {L}.{C}. and {T}ap, {J}. and {A}ron-{W}isnewsky, {J}. and {P}elloux, {V}. and {B}asdevant, {A}. and {B}ouillot, {J}. {L}. and {Z}ucker, {J}ean-{D}aniel and {D}ore, {J}. and {C}lement, {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {R}oux-en-{Y} gastric bypass ({RYGB}) surgery is one of the most efficient procedures for treating morbid obesity and results in weight-loss and improvements in metabolism and inflammation. {O}bjective: {W}e examined the impact of {RYGB} on modifications of gut microbiota and its potential associations with changes in gene expression in white adipose tissue ({WAT}). {D}esign: {G}ut microbiota were profiled from fecal samples by using pyrosequencing in morbidly obese individuals, explored before (0 mo), 3 mo after, and 6 mo after {RYGB}. {WAT} gene expression was studied at 0 and 3 mo. {W}e explored associations between microbial genera and differentially expressed genes in {WAT} and clinical markers. {R}esults: {T}he richness of gut microbiota increased after {RYGB}; 37% of increased bacteria belonged to {P}roteobacteria. {T}he associations between gut microbiota composition and {WAT} gene expression increased after {RYGB}. {F}ourteen discriminant bacterial genera (7 were dominant and 7 were subdominant) and 202 {WAT} genes changed after {RYGB}. {V}ariations in bacterial genera correlated with changes in both clinical phenotype and adipose tissue gene expression. {S}ome genes encode metabolic and inflammatory genes. {A}lmost half of the correlations were independent of the change in calorie intake. {C}onclusion: {T}hese results show an increase in gut microbiota richness and in the number of associations between gut microbiota and {WAT} genes after {RYGB} in obesity. {V}ariations of gut microbiota were associated with changes in {WAT} gene expression. {T}hese findings stimulate deeper explorations of the mechanisms linking gut microbiome and {WAT} pathological alterations in human obesity and its changes after weight loss.},
  keywords = {},
  booktitle = {},
  journal = {{A}merican {J}ournal of {C}linical {N}utrition},
  volume = {98},
  numero = {1},
  pages = {16--24},
  ISSN = {0002-9165},
  year = {2013},
  DOI = {10.3945/ajcn.113.058743},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060475},
}