Doucouré Souleymane, Cornélie Sylvie, Patramool S., Mouchet François, Demettre E., Seveno M., Dehecq J. S., Rutee H., Hervé Jean-Pierre, Favier F., Missé Dorothée, Gasque P., Remoué Franck. (2013). First screening of Aedes albopictus immunogenic salivary proteins. Insect Molecular Biology, 22 (4), p. 411-423. ISSN 0962-1075.
Titre du document
First screening of Aedes albopictus immunogenic salivary proteins
Année de publication
2013
Auteurs
Doucouré Souleymane, Cornélie Sylvie, Patramool S., Mouchet François, Demettre E., Seveno M., Dehecq J. S., Rutee H., Hervé Jean-Pierre, Favier F., Missé Dorothée, Gasque P., Remoué Franck
Source
Insect Molecular Biology, 2013,
22 (4), p. 411-423 ISSN 0962-1075
Study of the human antibody (Ab) response to Aedes salivary proteins can provide new biomarkers to evaluate human exposure to vector bites. The identification of genus-and/or species-specific proteins is necessary to improve the accuracy of biomarkers. We analysed Aedes albopictus immunogenic salivary proteins by 2D immunoproteomic technology and compared the profiles according to human individual exposure to Ae. albopictus or Ae. aegypti bites. Strong antigenicity to Ae. albopictus salivary proteins was detected in all individuals whatever the nature of Aedes exposure. Amongst these antigenic proteins, 68% are involved in blood feeding, including D7 protein family, adenosine deaminase, serpin and apyrase. This study provides an insight into the repertoire of Ae. albopictus immunogenic salivary proteins for the first time.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010060470]
Identifiant IRD
fdi:010060470
