%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Sabbagh, A.
%A Courtin, David
%A Milet, Jacqueline
%A Massaro, J. D.
%A Castelli, E. C.
%A Migot Nabias, Florence
%A Favier, B.
%A Rouas-Freiss, N.
%A Moreau, P.
%A Garcia, André
%A Donadi, E. A.
%T Association of HLA-G 3 ' untranslated region polymorphisms with antibody response against Plasmodium falciparum antigens : preliminary results
%D 2013
%L fdi:010060434
%G ENG
%J Tissue Antigens
%@ 0001-2815
%K antibody response ; family-based association ; haplotype analysis ; human ; leukocyte antigen-G ; malaria ; Plasmodium falciparum
%M ISI:000320178700008
%N 1
%P 53-58
%R 10.1111/tan.12140
%U https://www.documentation.ird.fr/hor/fdi:010060434
%> https://www.documentation.ird.fr/intranet/publi/2013/07/010060434.pdf
%V 82
%W Horizon (IRD)
%X Host and Plasmodium interactions result in highly variable clinical phenotypes, partly explained by the nature and level of anti-malarial antibody response. Human leukocyte antigen (HLA)-G can create a tolerogenic environment, allowing parasites to escape from anti-malarial immunity. We performed a family-based association study encompassing 483 Sereer individuals (261 children and their parents), and reported two independent signals at the HLA-G 3' untranslated region associated with antibody response to specific Plasmodium falciparum blood stage antigens, previously associated with malaria protection: (i) +3010G together with +3142C with total IgG and IgG1 against GLURP and (ii) +3196G with IgG3 against MSP2. While these results require further investigation, they suggest for the first time a role of HLA-G in the regulation of humoral immune response in malaria.
%$ 052 ; 050