%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Ibitokou, S.
%A Brutus, Laurent
%A Vianou, B.
%A Oesterholt, M.
%A Massougbodji, A.
%A Deloron, Philippe
%A Troye-Blomberg, M.
%A Fievet, Nadine
%A Luty, Adrian
%T Gestational age-related changes in the peripheral blood cell composition of sub-Saharan African women
%D 2013
%L fdi:010060425
%G ENG
%J Journal of Reproductive Immunology
%@ 0165-0378
%K Pregnancy ; Peripheral blood mononuclear cells ; African women ; Longitudinal cohort study ; Lymphocytes ; Antigen-presenting cells
%K AFRIQUE SUBSAHARIENNE
%M ISI:000320220500003
%N 1-2
%P 21-28
%R 10.1016/j.jri.2013.03.002
%U https://www.documentation.ird.fr/hor/fdi:010060425
%> https://www.documentation.ird.fr/intranet/publi/2013/07/010060425.pdf
%V 98
%W Horizon (IRD)
%X Gestational age-related changes in the cellular composition of peripheral blood have not been described in sub-Saharan African settings. We conducted longitudinal cohort studies in Beninese and Tanzanian mothers with quantification of peripheral blood mononuclear cell-types ex vivo using flow cytometry. Between the second trimester and delivery the frequency of CD4(+) T cells declined significantly, contrasting with a non-significant increase in CD8(+) T cells, but no changes in T-regulatory, NK or NKT cell frequencies. Antigen-presenting cell profiles were also unaltered, although non-significant trends were evident. These changes resemble in some respects those reported during pregnancies in developed countries, but differ in others.
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