@article{fdi:010060425, title = {{G}estational age-related changes in the peripheral blood cell composition of sub-{S}aharan {A}frican women}, author = {{I}bitokou, {S}. and {B}rutus, {L}aurent and {V}ianou, {B}. and {O}esterholt, {M}. and {M}assougbodji, {A}. and {D}eloron, {P}hilippe and {T}roye-{B}lomberg, {M}. and {F}ievet, {N}adine and {L}uty, {A}drian}, editor = {}, language = {{ENG}}, abstract = {{G}estational age-related changes in the cellular composition of peripheral blood have not been described in sub-{S}aharan {A}frican settings. {W}e conducted longitudinal cohort studies in {B}eninese and {T}anzanian mothers with quantification of peripheral blood mononuclear cell-types ex vivo using flow cytometry. {B}etween the second trimester and delivery the frequency of {CD}4(+) {T} cells declined significantly, contrasting with a non-significant increase in {CD}8(+) {T} cells, but no changes in {T}-regulatory, {NK} or {NKT} cell frequencies. {A}ntigen-presenting cell profiles were also unaltered, although non-significant trends were evident. {T}hese changes resemble in some respects those reported during pregnancies in developed countries, but differ in others.}, keywords = {{P}regnancy ; {P}eripheral blood mononuclear cells ; {A}frican women ; {L}ongitudinal cohort study ; {L}ymphocytes ; {A}ntigen-presenting cells ; {AFRIQUE} {SUBSAHARIENNE}}, booktitle = {}, journal = {{J}ournal of {R}eproductive {I}mmunology}, volume = {98}, numero = {1-2}, pages = {21--28}, ISSN = {0165-0378}, year = {2013}, DOI = {10.1016/j.jri.2013.03.002}, URL = {https://www.documentation.ird.fr/hor/fdi:010060425}, }