@article{fdi:010060417,
  title = {{A}ssociation of {IL}-4 and {IL}-10 maternal haplotypes with immune responses to {P}. falciparum in mothers and newborns},
  author = {{L}okossou, {A}. {G}. and {D}echavanne, {C}{\'e}lia and {B}ouraima, {A}. and {C}ourtin, {D}avid and {L}e {P}ort, {A}. and {L}adekpo, {R}. and {N}oukpo, {J}. and {B}onou, {D}. and {A}houangninou, {C}. and {S}abbagh, {A}. and {F}ayomi, {B}. and {M}assougbodji, {A}. and {G}arcia, {A}ndr{\'e} and {M}igot {N}abias, {F}lorence},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {P}articular cytokine gene polymorphisms are involved in the regulation of the antibody production. {T}he consequences of already described {IL}-4, {IL}-10 and {IL}-13 gene polymorphisms on biological parameters and antibody levels were investigated among 576 mothers at delivery and their newborns in the context of {P}. falciparum placental malaria infection. {M}ethods: {T}he study took place in the semi-rural area of {T}ori-{B}ossito, in south-west {B}enin, where malaria is meso-endemic. {S}ix biallelic polymorphisms were determined by quantitative {PCR} using {T}aq{M}an ({R}) {P}re {D}esigned {SNP} {G}enotyping {A}ssays, in {IL}-4 (rs2243250, rs2070874), {IL}-10 (rs1800896, rs1800871, rs1800872) and {IL}-13 (rs1800925) genes. {A}ntibody responses directed to {P}. falciparum {MSP}-1, {MSP}-2, {MSP}-3, {GLURP}-{R}0, {GLURP}-{R}2 and {AMA}-1 recombinant proteins were determined by {ELISA}. {R}esults: {T}he maternal {IL}-4(-590)*{T}/{IL}-4(+33)*{T} haplotype (one or two copies) was associated with favorable maternal condition at delivery (high haemoglobin levels, absence of placental parasites) and one of its component, the {IL}-4(-590) {TT} genotype, was related to low {I}g{G} levels to {MSP}-1, {MSP}-2/3{D}7 and {MSP}-2/{FC}27. {I}nversely, the maternal {IL}-10(-1082) {AA} was positively associated with {P}. falciparum placenta infection at delivery. {A}s a consequence, the {IL}-10(-819)*{T} allele (in {CT} and {TT} genotypes) as well as the {IL}-10(-1082)*{A}/{IL}-10(-819)*{T}/{IL}-10(-592)*{A} haplotype (one or two copies) in which it is included, were related to an increased risk for anaemia in newborns. {T}he maternal {IL}-10(-1082) {AA} genotype was related to high {I}g{G} levels to {MSP}-2/3{D}7 and {AMA}-1 in mothers and newborns, respectively. {T}he {IL}-13 gene polymorphism was only involved in the newborn's antibody response to {AMA}-1. {C}onclusion: {T}hese data revealed that {IL}-4 and {IL}-10 maternal gene polymorphisms are likely to play a role in the regulation of biological parameters in pregnant women at delivery (anaemia, {P}. falciparum placenta infection) and in newborns (anaemia). {M}oreover, {IL}-4, {IL}-10 and {IL}-13 maternal gene polymorphisms were related to {I}g{G} responses to {MSP}-1, {MSP}-2/3{D}7 and {MSP}-2/{FC}27 in mothers as well as to {AMA}-1 in newborns.},
  keywords = {{M}alaria ; {P}. falciparum ; {C}ytokine gene polymorphisms ; {IL}-4 ; {IL}-10 ; {IL}-13 ; {P}regnancy ; {C}ord blood ; {R}ecombinant proteins ; {S}pecific antibodies},
  booktitle = {},
  journal = {{B}mc {I}nfectious {D}iseases},
  volume = {13},
  numero = {},
  pages = {215},
  ISSN = {1471-2334},
  year = {2013},
  DOI = {10.1186/1471-2334-13-215},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060417},
}